Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation

T. Yoshikawa, S. Handa, K. Nagami, M. Suzuki, Yumiko Wainai, T. Minami, K. Suzuki, S. Kitazawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study was performed to determine the effects of the angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR + C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C than in S. For each of these parameters, the opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium.

Original languageEnglish
Pages (from-to)91-100
Number of pages10
JournalJapanese Heart Journal
Volume36
Issue number1
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Aortic Valve Insufficiency
Ventricular Function
Angiotensin-Converting Enzyme Inhibitors
Adrenergic Receptors
Rabbits
High Cardiac Output
Ventricular Remodeling
Aortic Valve
Stomach
Myocardium
Norepinephrine
Heart Failure
Hemodynamics
alacepril
Blood Pressure
Weights and Measures

Keywords

  • Angiotensin-converting enzyme inhibitor
  • Aortic regurgitation
  • Beta-adrenoceptor
  • Catecholamine
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation. / Yoshikawa, T.; Handa, S.; Nagami, K.; Suzuki, M.; Wainai, Yumiko; Minami, T.; Suzuki, K.; Kitazawa, S.

In: Japanese Heart Journal, Vol. 36, No. 1, 1995, p. 91-100.

Research output: Contribution to journalArticle

Yoshikawa, T. ; Handa, S. ; Nagami, K. ; Suzuki, M. ; Wainai, Yumiko ; Minami, T. ; Suzuki, K. ; Kitazawa, S. / Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation. In: Japanese Heart Journal. 1995 ; Vol. 36, No. 1. pp. 91-100.
@article{c3b44a902e2a41e1a85cb26a265f6f33,
title = "Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation",
abstract = "This study was performed to determine the effects of the angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR + C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C than in S. For each of these parameters, the opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium.",
keywords = "Angiotensin-converting enzyme inhibitor, Aortic regurgitation, Beta-adrenoceptor, Catecholamine, Heart failure",
author = "T. Yoshikawa and S. Handa and K. Nagami and M. Suzuki and Yumiko Wainai and T. Minami and K. Suzuki and S. Kitazawa",
year = "1995",
language = "English",
volume = "36",
pages = "91--100",
journal = "International Heart Journal",
issn = "1349-2365",
publisher = "International Heart Journal Association",
number = "1",

}

TY - JOUR

T1 - Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation

AU - Yoshikawa, T.

AU - Handa, S.

AU - Nagami, K.

AU - Suzuki, M.

AU - Wainai, Yumiko

AU - Minami, T.

AU - Suzuki, K.

AU - Kitazawa, S.

PY - 1995

Y1 - 1995

N2 - This study was performed to determine the effects of the angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR + C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C than in S. For each of these parameters, the opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium.

AB - This study was performed to determine the effects of the angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR + C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C than in S. For each of these parameters, the opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium.

KW - Angiotensin-converting enzyme inhibitor

KW - Aortic regurgitation

KW - Beta-adrenoceptor

KW - Catecholamine

KW - Heart failure

UR - http://www.scopus.com/inward/record.url?scp=0028930386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028930386&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 91

EP - 100

JO - International Heart Journal

JF - International Heart Journal

SN - 1349-2365

IS - 1

ER -