Effect of the Angiotensin-converting Enzyme Inhibitor Alacepril on Ventricular Function and Beta-Adrenoceptor Number in Rabbits with Aortic Regurgitation

Tsutomu Yoshikawa, Shunnosuke Handa, Keiichi Nagami, Masahiro Suzuki, Yumiko Wainai, Takeo Minami, Kazutoshi Suzuki, Shikifumi Kitazawa

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Abstract

This study was performed to determine the effects of die angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR-f-C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C man in S. For each of these parameters, die opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium. (Jpn Heart J 36: 91-100, 1995).

Original languageEnglish
Pages (from-to)91-100
Number of pages10
Journaljapanese heart journal
Volume36
Issue number1
DOIs
Publication statusPublished - 1995 Jan 1

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Keywords

  • angiotensin-converting
  • aortic
  • beta-adrenoceptor
  • catecholamine
  • enzyme
  • failure
  • heart
  • inhibitor
  • regurgitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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