Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ™) on cognitive functions

Yuji Itoh, Kyoko Hine, Hiroshi Miura, Tatsuo Uetake, Masahiko Nakano, Naohiro Takemura, Kaoru Sakatani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Pyrroloquinoline quinone (PQQ) is a quinone compound first identified in 1979. It has been reported that rats fed a PQQ-supplemented diet showed better learning ability than controls, suggesting that PQQ may be useful for improving memory in humans. In the present study, a randomized, placebo-controlled, doubleblinded study to examine the effect of PQQ disodium salt (BioPQQ™) on cognitive functions was conducted with 41 elderly healthy subjects. Subjects were orally given 20 mg of BioPQQ™ per day or placebo, for 12 weeks. For cognitive functions, selective attention by the Stroop and reverse Stroop test, and visualspatial cognitive function by the laptop tablet Touch M, were evaluated. In the Stroop test, the change of Stroop interference ratios (SIs) for the PQQ group was significantly smaller than for the placebo group. In the Touch M test, the stratification analyses dividing each group into two groups showed that only in the lower group of the PQQ group (initial score<70), did the score significantly increase. Measurements of physiological parameters indicated no abnormal blood or urinary adverse events, nor adverse internal or physical examination findings at any point in the study. The preliminary experiment using near-infrared spectrometry (NIRS) suggests that cerebral blood flow in the prefrontal cortex was increased by the administration of PQQ. The results suggest that PQQ can prevent reduction of brain function in aged persons, especially in attention and working memory.

Original languageEnglish
Title of host publicationOxygen Transport to Tissue XXXVII
EditorsClare E. Elwell, Terence S. Leung, David K. Harrison
PublisherSpringer New York LLC
Pages319-325
Number of pages7
ISBN (Print)9781493930227
DOIs
Publication statusPublished - 2016
Event42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
Duration: 2014 Jun 282014 Jul 3

Publication series

NameAdvances in Experimental Medicine and Biology
Volume876
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Other

Other42nd Annual Meeting of International Society on Oxygen Transport to Tissue
CountryUnited Kingdom
CityLondon
Period14/6/2814/7/3

Keywords

  • Attention
  • Brain
  • Memory
  • Pqq
  • Supplement

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Itoh, Y., Hine, K., Miura, H., Uetake, T., Nakano, M., Takemura, N., & Sakatani, K. (2016). Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ™) on cognitive functions. In C. E. Elwell, T. S. Leung, & D. K. Harrison (Eds.), Oxygen Transport to Tissue XXXVII (pp. 319-325). (Advances in Experimental Medicine and Biology; Vol. 876). Springer New York LLC. https://doi.org/10.1007/978-1-4939-3023-4_40