Effect of thickness of superficial tissues on the spatial sensitivity profile for optical imaging

    Research output: Contribution to journalConference article


    It is important for near-infrared imaging to estimate the sensitivity of detected signal to the change in absorption of tissue resulting from brain activation and the volume of tissue interrogated for a specific source-detector spacing. In this study, light propagation in adult head models is predicted by Monte Carlo simulation in order to investigate the effect of the thickness of the superficial tissues on the partial optical path length in the brain and on the spatial sensitivity profile. The effect of thickness of skull on the partial optical path length and spatial sensitivity profile is almost the same as that of the scalp. The effect of thickness of cerebrospinal fluid layer on the partial optical path length and spatial sensitivity profile is different from that of the scalp and skull. The partial optical path length mainly depends upon the depth of inner skull surface whilst the spatial sensitivity profile is considerably affected by the thickness of the cerebrospinal fluid layer.

    Original languageEnglish
    Pages (from-to)160-167
    Number of pages8
    JournalProceedings of SPIE - The International Society for Optical Engineering
    Publication statusPublished - 2003 Dec 1
    EventPhoton Migration and Diffuse-Light Imaging - Munich, Germany
    Duration: 2003 Jun 222003 Jun 23



    • Near infrared spectroscopy
    • Spatial sensitivity profile
    • Topographic imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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