Effect on cortical blood flow of electrical stimulation of trigeminal cerebrovascular nerve fibres in the rat

N. Suzuki, J. E. Hardebo, J. Kahrstrom, Ch Owman

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

It has recently been demonstrated in the rat that the majority of cerebrovascular pain fibres containing immunoreactive substance P and calcitonin gene-related peptide reach the vessels via the nasociliary nerve, a branch of the ophthalmic trigeminal division. In order to elucidate the effect of these nerves on blood flow in vivo, the relative changes in cortical microvascular flow were continuously monitored by a laser-Doppler flowmeter system during electrical nerve stimulation, with the central nerve connection cut and after removal of neighbouring dilatory parasympathetic nerves. The nasociliary nerve on one side was stimulated proximal to the ethmoidal foramen by a bipolar platinum electrode. Activation at different frequencies, continuously, or as bursts with a constant voltage, impulse duration and total stimulus length, revealed that a maximum increase in blood flow amounting to 16.7% after 36 s was obtained with continuous stimulation at 10 Hz. Flow markedly declined during the following 1-min stimulation period. No changes in contralateral cortical blood flow, mean arterial blood pressure or blood gases were observed during or after stimulation. The present study demonstrates for the first time that direct and selective electrical activation of trigeminal cerebrovascular nerves induces an increase, albeit small and transient, in blood flow within the brain.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalActa Physiologica Scandinavica
Volume138
Issue number3
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Trigeminal Nerve
Nerve Fibers
Electric Stimulation
Arterial Pressure
Flowmeters
Calcitonin Gene-Related Peptide
Substance P
Platinum
Electrodes
Lasers
Gases
Pain
Brain

Keywords

  • Cerebral blood flow
  • Electrical nerve stimulation
  • Sensory nerve fibres
  • Trigeminal nerve

ASJC Scopus subject areas

  • Physiology

Cite this

Effect on cortical blood flow of electrical stimulation of trigeminal cerebrovascular nerve fibres in the rat. / Suzuki, N.; Hardebo, J. E.; Kahrstrom, J.; Owman, Ch.

In: Acta Physiologica Scandinavica, Vol. 138, No. 3, 1990, p. 307-315.

Research output: Contribution to journalArticle

Suzuki, N. ; Hardebo, J. E. ; Kahrstrom, J. ; Owman, Ch. / Effect on cortical blood flow of electrical stimulation of trigeminal cerebrovascular nerve fibres in the rat. In: Acta Physiologica Scandinavica. 1990 ; Vol. 138, No. 3. pp. 307-315.
@article{75faa226b3f547caa5be5fe17ae08709,
title = "Effect on cortical blood flow of electrical stimulation of trigeminal cerebrovascular nerve fibres in the rat",
abstract = "It has recently been demonstrated in the rat that the majority of cerebrovascular pain fibres containing immunoreactive substance P and calcitonin gene-related peptide reach the vessels via the nasociliary nerve, a branch of the ophthalmic trigeminal division. In order to elucidate the effect of these nerves on blood flow in vivo, the relative changes in cortical microvascular flow were continuously monitored by a laser-Doppler flowmeter system during electrical nerve stimulation, with the central nerve connection cut and after removal of neighbouring dilatory parasympathetic nerves. The nasociliary nerve on one side was stimulated proximal to the ethmoidal foramen by a bipolar platinum electrode. Activation at different frequencies, continuously, or as bursts with a constant voltage, impulse duration and total stimulus length, revealed that a maximum increase in blood flow amounting to 16.7{\%} after 36 s was obtained with continuous stimulation at 10 Hz. Flow markedly declined during the following 1-min stimulation period. No changes in contralateral cortical blood flow, mean arterial blood pressure or blood gases were observed during or after stimulation. The present study demonstrates for the first time that direct and selective electrical activation of trigeminal cerebrovascular nerves induces an increase, albeit small and transient, in blood flow within the brain.",
keywords = "Cerebral blood flow, Electrical nerve stimulation, Sensory nerve fibres, Trigeminal nerve",
author = "N. Suzuki and Hardebo, {J. E.} and J. Kahrstrom and Ch Owman",
year = "1990",
language = "English",
volume = "138",
pages = "307--315",
journal = "Acta Physiologica Scandinavica",
issn = "0370-839X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Effect on cortical blood flow of electrical stimulation of trigeminal cerebrovascular nerve fibres in the rat

AU - Suzuki, N.

AU - Hardebo, J. E.

AU - Kahrstrom, J.

AU - Owman, Ch

PY - 1990

Y1 - 1990

N2 - It has recently been demonstrated in the rat that the majority of cerebrovascular pain fibres containing immunoreactive substance P and calcitonin gene-related peptide reach the vessels via the nasociliary nerve, a branch of the ophthalmic trigeminal division. In order to elucidate the effect of these nerves on blood flow in vivo, the relative changes in cortical microvascular flow were continuously monitored by a laser-Doppler flowmeter system during electrical nerve stimulation, with the central nerve connection cut and after removal of neighbouring dilatory parasympathetic nerves. The nasociliary nerve on one side was stimulated proximal to the ethmoidal foramen by a bipolar platinum electrode. Activation at different frequencies, continuously, or as bursts with a constant voltage, impulse duration and total stimulus length, revealed that a maximum increase in blood flow amounting to 16.7% after 36 s was obtained with continuous stimulation at 10 Hz. Flow markedly declined during the following 1-min stimulation period. No changes in contralateral cortical blood flow, mean arterial blood pressure or blood gases were observed during or after stimulation. The present study demonstrates for the first time that direct and selective electrical activation of trigeminal cerebrovascular nerves induces an increase, albeit small and transient, in blood flow within the brain.

AB - It has recently been demonstrated in the rat that the majority of cerebrovascular pain fibres containing immunoreactive substance P and calcitonin gene-related peptide reach the vessels via the nasociliary nerve, a branch of the ophthalmic trigeminal division. In order to elucidate the effect of these nerves on blood flow in vivo, the relative changes in cortical microvascular flow were continuously monitored by a laser-Doppler flowmeter system during electrical nerve stimulation, with the central nerve connection cut and after removal of neighbouring dilatory parasympathetic nerves. The nasociliary nerve on one side was stimulated proximal to the ethmoidal foramen by a bipolar platinum electrode. Activation at different frequencies, continuously, or as bursts with a constant voltage, impulse duration and total stimulus length, revealed that a maximum increase in blood flow amounting to 16.7% after 36 s was obtained with continuous stimulation at 10 Hz. Flow markedly declined during the following 1-min stimulation period. No changes in contralateral cortical blood flow, mean arterial blood pressure or blood gases were observed during or after stimulation. The present study demonstrates for the first time that direct and selective electrical activation of trigeminal cerebrovascular nerves induces an increase, albeit small and transient, in blood flow within the brain.

KW - Cerebral blood flow

KW - Electrical nerve stimulation

KW - Sensory nerve fibres

KW - Trigeminal nerve

UR - http://www.scopus.com/inward/record.url?scp=0025241872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025241872&partnerID=8YFLogxK

M3 - Article

VL - 138

SP - 307

EP - 315

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0370-839X

IS - 3

ER -