Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation

Masayoshi Shinjo(H), Isao Miyairi, Ken Hoshino, Takao Takahashi, Tetsuo Nakayama

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Immunizations using live-attenuated vaccines are not recommended for post-liver transplant children due to its theoretical risks. However, they will encounter vaccine-preventable viral diseases upon returning to real-life situations. We performed a total of 70 immunizations with four individual live-attenuated vaccines to 18 pediatric post-living donor liver transplant (LDLT) recipients who fulfilled a clinical criteria including humoral and cell-mediated immunity. The seroconversion rates at the first dose for measles (strain AIK-C), rubella (strain TO-336), varicella (strain Oka), and mumps (strains Hoshino) were 100% (15/15), 100% (15/15), 82% (9/11), and 82% (9/11), respectively. During observed period (-5 years 11 months), a few cases with waning immunity (antibodies were once produced but the levels fell over time) were seen except after rubella immunization. Clinical diseases after seroconversion or definite serious adverse effects due to immunization were not observed. Immunizations using selected live-attenuated vaccines were safe and effective for post-LDLT children who were not severely immunosuppressed.

Original languageEnglish
Pages (from-to)6859-6863
Number of pages5
JournalVaccine
Volume26
Issue number52
DOIs
Publication statusPublished - 2008 Dec 9

Fingerprint

liver transplant
Attenuated Vaccines
Living Donors
live vaccines
Liver Transplantation
Immunization
immunization
Rubella
seroconversion
Liver
Transplants
Mumps
Chickenpox
Measles
Virus Diseases
Cellular Immunity
Immunity
cell-mediated immunity
Vaccines
Pediatrics

Keywords

  • Children
  • Immunization
  • Live-attenuated
  • Liver transplantation

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. / Shinjo(H), Masayoshi; Miyairi, Isao; Hoshino, Ken; Takahashi, Takao; Nakayama, Tetsuo.

In: Vaccine, Vol. 26, No. 52, 09.12.2008, p. 6859-6863.

Research output: Contribution to journalArticle

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