Effectiveness and safety of chemoradiation in a community-based population of patients with esophageal cancer

Akira Goto, Yuka Hasegawa, Yasutaka Sukawa, Kenichi Fujii, Yasutaka Matunaga, Kazuya Suzuki, Kazuhiko Yonezawa, Takashi Abe, Hideki Wakasugi, Miki Itoh, Ayako Itoh, Yasuhisa Shinomura, Kenzi Kagei

Research output: Contribution to journalArticle

Abstract

Background: In Japan, esophagectomy with three-field lymphadenectomy is the standard therapy for resectable esophageal cancer. However, its outcome is considered unsatisfactory because the 5-year survival rate is less than 50%. Chemoradiotherapy (CRT) is the standard therapy for unresectable esophageal cancer and could also be considered as an option for resectable esophageal cancer. We retrospectively determined the efficacy and safety of CRT for patients with esophageal cancer. Methods: The study population comprised patients with esophageal cancer who had been treated with CRT between April 2004 and October 2009 in our institute. Acute and late toxicity was assessed with NCI-CTC and RTOG/EORTC late radiation morbidity scoring scheme, respectively. Survival time was calculated using Kaplan-Meier methods. Results: We enrolled 29 consecutive patients and classified them on the basis of clinical staging: stage 1, 4 patients; stage II/III, 11 patients; and stage IV, 14 patients. Complete response was achieved in 37.9% and 45.5% of the total study population and the stage II/III group, respectively. The median survival time in these groups was 12.1 months and 15 months, respectively. Grade 3/4 acute toxicities were observed in 62.1% of the patients. Grade 3/4 late toxicities were observed in 12% of the patients. The first failure after CRT was almost locoregional. Conclusion: CRT appears to be an effective therapy for esophageal cancer; however, its outcome is not satisfactory. Therefore, it is necessary to evaluate the role of salvage surgery after CRT and new chemotherapeutic agents.

Original languageEnglish
Pages (from-to)2115-2119
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number11
Publication statusPublished - 2010 Nov 6

Keywords

  • Chemoradiotherapy
  • Esophageal cancer
  • Salvage
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Goto, A., Hasegawa, Y., Sukawa, Y., Fujii, K., Matunaga, Y., Suzuki, K., Yonezawa, K., Abe, T., Wakasugi, H., Itoh, M., Itoh, A., Shinomura, Y., & Kagei, K. (2010). Effectiveness and safety of chemoradiation in a community-based population of patients with esophageal cancer. Japanese Journal of Cancer and Chemotherapy, 37(11), 2115-2119.