Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study

Koichi Ida, Tsutomu Miyamoto, Shotaro Higuchi, Hodaka Takeuchi, Satoshi Yamada, Motoki Ono, Hiroshi Nishihara, Tanri Shiozawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To increase diagnostic efficiency and cost-effectiveness, we performed an exploratory genetic test using a newly designed panel containing 28 actionable and druggable genes, alterations in which are frequently reported in gynecological cancers (TANRE-G, Targeted variants ANalysis RElated to Gynecological cancers). Samples consisted of the formalin-fixed, paraffin-embedded tissue of endometrial (4 cases), cervical (3 cases), and ovarian (4 cases) carcinomas. The sequencing procedure was performed using Ion PGM in our institute with related sequencing kits, and data were analyzed using ClinVar. The present system achieved more than 2500 reads in all tumor samples, and enabled a copy number variation analysis. Results showed that actionable and druggable mutations were detected in 82% (9/11) and 64% (7/11) of cases, respectively, which was similar to other commercially available genetic tests. The amplification of MYC and KRAS was also detected. The analysis cost for each sample was JPY 94,000 (USD 850). These results demonstrate the potential of the TANRE-G panel as an effective tool for examining genetic alterations in gynecological cancers.

Original languageEnglish
Article number62
JournalMedical Oncology
Issue number7
Publication statusPublished - 2019 Jul 1


  • Cervical carcinoma
  • Endometrial carcinoma
  • Gene panel
  • Genetic test
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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