Effectiveness of indocyanine green fluorescence in endoscopic marking in gastric cancer surgery: A feasibility study for replacing India ink

Hiromi Ono, Mitsuo Kusano, Masashi Nihei, Hideyuki Hayashi, Hiraku Fukushima, Masato Kawakami, Yasushi Danjo, Kimimoto Nagashima, Yuichi Shimizu, Futoshi Kawamata, Shohei Honda, Tsuyoshi Shimamura, Hiroshi Nishihara

Research output: Contribution to journalArticle


When injected, indocyanine green (ICG) immediately combines with lipoproteins to fluoresce. Here, we studied whether ICG fluorescence is effective for endoscopic marking in gastric cancer surgery using a photodynamic eye (PDE) camera and fluorescent endoscope. An ICG solution was endoscopically injected into the submucosal layer of the gastric tumor 3 days before surgery. We observed the lesions using both a PDE camera and a fluorescent endoscope during laparotomy and laparoscopy, respectively; we also observed the fluorescent luminance and fluorescent size of the resected lesions. We could intraoperatively detect the size of the resected lesions in eight patients with early gastric cancer and six patients with advanced gastric cancer. We believe that the use of ICG fluorescence in endoscopic marking requires additional information, such as the volume of the ICG solution and the timing of the ICG injection.

Original languageEnglish
Pages (from-to)385-393
Number of pages9
JournalJournal of Japanese Society of Gastroenterology
Issue number4
Publication statusPublished - 2018 Jan 1
Externally publishedYes


ASJC Scopus subject areas

  • Gastroenterology

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