Effectiveness of lidocaine infusion for status epilepticus in childhood: A retrospective multi-institutional study in Japan

Hideji Hattori, Tsunekazu Yamano, Kitami Hayashi, Makiko Osawa, Kyoko Kondo, Masao Aihara, Kazuhiro Haginoya, Shinichiro Hamano, Tatsurou Izumi, Kenichiro Kaneko, Ikuko Kato, Makoto Matsukura, Kimio Minagawa, Toshio Miura, Yoko Ohtsuka, Kenji Sugai, Takao Takahashi, Hideo Yamanouchi, Hitoshi Yamamoto, Hideto Yoshikawa

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Abstract

We evaluated the usefulness of intravenous lidocaine therapy for managing of status epilepticus (SE) during childhood in a retrospective multi-institutional study. Questionnaires were sent to 28 hospitals concerning patients admitted for SE who were managed with lidocaine, assessing patient characteristics, treatment protocols and efficacy. In 279 treated patients, 261 SE occurrences at ages between 1 month and 15 years were analyzed. SE was classified as showing continuous, clustered, or frequently repeated seizures. Considering efficacy and side effects in combination, the usefulness of lidocaine was classified into six categories: extremely useful, useful, slightly useful, not useful, associated with deterioration, or unevaluated. In 148 SE cases (56.7%), lidocaine was rated as useful or extremely useful. Multivariate analysis indicated lidocaine was to be useful in SE with clustered and frequently repeated seizures, and SE attributable to certain acute illnesses, such as convulsions with mild gastroenteritis. Efficacy was poor when SE caused by central nervous system (CNS) infectious disease. Standard doses (approximately 2 mg/kg as a bolus, 2 mg/kg/h as maintenance) produced better outcomes than lower or higher doses. Poor responders to the initial bolus injection of lidocaine were less likely to respond to subsequent continuous infusion than good initial responders. We recommend lidocaine for use in SE with clustered or frequently repeated seizures, and in SE associated with benign infantile convulsion and convulsions with mild gastroenteritis. Lidocaine should be initiated with a bolus of 2 mg/kg. If SE is arrested by the bolus, continuous maintenance infusion should follow; treatment should proceed to different measures when SE shows a poor response to the initial bolus of lidocaine.

Original languageEnglish
Pages (from-to)504-512
Number of pages9
JournalBrain and Development
Volume30
Issue number8
DOIs
Publication statusPublished - 2008 Sep 1

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Keywords

  • Childhood
  • Lidocaine
  • Multivariate analysis
  • Status epilepticus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Hattori, H., Yamano, T., Hayashi, K., Osawa, M., Kondo, K., Aihara, M., Haginoya, K., Hamano, S., Izumi, T., Kaneko, K., Kato, I., Matsukura, M., Minagawa, K., Miura, T., Ohtsuka, Y., Sugai, K., Takahashi, T., Yamanouchi, H., Yamamoto, H., & Yoshikawa, H. (2008). Effectiveness of lidocaine infusion for status epilepticus in childhood: A retrospective multi-institutional study in Japan. Brain and Development, 30(8), 504-512. https://doi.org/10.1016/j.braindev.2007.12.016