Effectiveness of mass screening for endometrial cancer

Chikako Nakagawa-Okamura, Shinji Sato, Ichiro Tsuji, Hiroyuki Kuramoto, Yoshitaka Tsubono, Daisuke Aoki, Toshiko Jobo, Mineo Oomura, Shigeru Hisamichi, Akira Yajima

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the effectiveness of mass screening for endometrial cancer using Endocyte (Laboratoire CCD, Paris, France) endometrial smears. Screening with endometrial smears has the potential to reduce mortality from endometrial cancer. STUDY DESIGN: The study subjects were consecutive patients with documented endometrial cancer diagnosed between January 1, 1989, and December 31, 1997, at 22 hospitals in Japan, One hundred twenty-six cases were detected by mass screening and 1,069 diagnosed in outpatient clinics. We compared the stage of cancer at diagnosis and survival rate of patients in the two groups. RESULTS: Early stage was significantly more frequent in the screening group (P<.001); stage I comprised 88.1% of the screening group as compared with 65.3% of the outpatient group. Well-differentiated adenocarcinoma was significantly more frequent in the screening group (P<.01); grade 1 constituted 74.7% of the screening group as compared with 61.0% of the outpatient group. The five-year survival rate was significantly higher in the screening group than in the outpatient group (94.0% vs. 84.3%, P =.041). The crude hazard ratio (HR) of dying of endometrial cancer for the screening group as compared to the outpatient group was .47 (95% CI .22-.99, P =.048). HR became .96 (95% CI .45-2.08, P =.925) after adjustment for age, study area and cancer stage. CONCLUSION: The results suggest that an endometrial cancer screening program would lead to early detection and improved survival among women with endometrial cancer.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalActa Cytologica
Volume46
Issue number2
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Mass Screening
Endometrial Neoplasms
Outpatients
Early Detection of Cancer
Survival Rate
Paris
Ambulatory Care Facilities
France
Neoplasms
Japan
Adenocarcinoma
Survival
Mortality

Keywords

  • Endocyte
  • Endometrial neoplasms
  • Mass screening
  • Survival analysis
  • Survival rate

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Nakagawa-Okamura, C., Sato, S., Tsuji, I., Kuramoto, H., Tsubono, Y., Aoki, D., ... Yajima, A. (2002). Effectiveness of mass screening for endometrial cancer. Acta Cytologica, 46(2), 277-283.

Effectiveness of mass screening for endometrial cancer. / Nakagawa-Okamura, Chikako; Sato, Shinji; Tsuji, Ichiro; Kuramoto, Hiroyuki; Tsubono, Yoshitaka; Aoki, Daisuke; Jobo, Toshiko; Oomura, Mineo; Hisamichi, Shigeru; Yajima, Akira.

In: Acta Cytologica, Vol. 46, No. 2, 2002, p. 277-283.

Research output: Contribution to journalArticle

Nakagawa-Okamura, C, Sato, S, Tsuji, I, Kuramoto, H, Tsubono, Y, Aoki, D, Jobo, T, Oomura, M, Hisamichi, S & Yajima, A 2002, 'Effectiveness of mass screening for endometrial cancer', Acta Cytologica, vol. 46, no. 2, pp. 277-283.
Nakagawa-Okamura C, Sato S, Tsuji I, Kuramoto H, Tsubono Y, Aoki D et al. Effectiveness of mass screening for endometrial cancer. Acta Cytologica. 2002;46(2):277-283.
Nakagawa-Okamura, Chikako ; Sato, Shinji ; Tsuji, Ichiro ; Kuramoto, Hiroyuki ; Tsubono, Yoshitaka ; Aoki, Daisuke ; Jobo, Toshiko ; Oomura, Mineo ; Hisamichi, Shigeru ; Yajima, Akira. / Effectiveness of mass screening for endometrial cancer. In: Acta Cytologica. 2002 ; Vol. 46, No. 2. pp. 277-283.
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