@article{694619fca2404860bf4a4ba467ea0894,
title = "Effectiveness of mindfulness-based cognitive therapy in patients with anxiety disorders in secondary-care settings: A randomized controlled trial",
abstract = "Aim: The primary objective of this study was to examine the effectiveness of mindfulness-based cognitive therapy (MBCT) in secondary-care settings where the vast majority of the patients have already undergone pharmacotherapy but have not remitted. Methods: Eligible participants were aged between 20 and 75 years and met the criteria for panic disorder/agoraphobia or social anxiety disorder specified in the DSM-IV. They were randomly assigned to either the MBCT group (n = 20) or the wait-list control group (n = 20). The primary outcome was the difference in mean change scores between pre- and post-intervention assessments on the State–Trait Anxiety Inventory (STAI). The outcome was analyzed using an intent-to-treat approach and a mixed-effect model repeated measurement. Results: We observed significant differences in mean change scores for the STAI State Anxiety subscale (difference, −10.1; 95% confidence interval, −16.9 to −3.2; P < 0.005) and STAI Trait Anxiety subscale (difference, −11.7; 95% confidence interval, −17.0 to −6.4; P < 0.001) between the MBCT and control groups. Conclusion: MBCT is effective in patients with anxiety disorders in secondary-care settings where the vast majority of patients are treatment-resistant to pharmacotherapy.",
keywords = "anxiety disorders, cognitive behavioral therapy, mindfulness, randomized controlled trial, secondary care",
author = "Akira Ninomiya and Mitsuhiro Sado and Sunre Park and Daisuke Fujisawa and Teppei Kosugi and Atsuo Nakagawa and Joichiro Shirahase and Masaru Mimura",
note = "Funding Information: This study was funded by Grant‐in‐Aid for Scientific Research of the Ministry of Education, Culture, Sport, Science, and Technology (KAKENHI Grant Number: 25460629.) The funding source had no role in study design, in data collection, analysis and interpretation; in the writing of the report; or in the decision to submit the paper for publication. Dr Ninomiya reports personal fees from Mochida Pharmaceutical Co., Ltd. and grants from Sony Corporate Services Corporation outside the submitted work. Dr Sado reports grants from the Japanese Ministry of Education, Culture, Sport, Science, and Technology during the conduct of the study; personal fees from Shionogi & Co., Ltd.; and grants and personal fees from Meiji Seika Pharma Co., Ltd., Hisamitsu Pharmaceutical Co., Inc., Mochida Pharmaceutical Co., Ltd., and Terumo Corporation outside the submitted work. Dr Fujisawa reports personal fees from Yoshitomiyakuhin Corporation, Meiji Seika Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., Pfizer Inc., and Mitsubishi Tanabe Pharma Corporation outside the submitted work. Dr Nakagawa reports royalties from Igaku‐Shoin and Kongo‐Shuppan; lecture fees from Dainippon‐Sumitomo Pharma, Pfizer, Yoshitomi Yakuhin, Otsuka Pharmaceutical, Meiji Seika, Tsumura & Co., and Mitsubishi Tanabe Pharma outside the submitted work. Dr Shirahase reports personal fees from Yoshitomiyakuhin Corporation, Shionogi & Co., Ltd., Meiji Seika Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K, frOtsuka Pharmaceutical Co., Ltd., and Pfizer Inc.; and grants from Sony Corporate Services Corporation outside the submitted work. Dr Mimura reports grants and personal fees from Tsumura, Nishikawa‐sangyo, and Teijin Pharma; personal fees from Chugai Pharmaceutical, Yoshitomiyakuhin Corporation, Shionogi &Co., Ltd., Novartis Pharma K.K, Meiji Seika Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., Eli Lilly Japan K.K, Janssen Pharmaceutical K.K, Fujifilm RI Pharma Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Eisai Co., Ltd., and Asahi Kasei Pharma Corporation; and personal fees from Astellas Pharma Inc., MSD K.K, Otsuka Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd., and Pfizer Inc. outside the submitted work. Publisher Copyright: {\textcopyright} 2019 The Authors. Psychiatry and Clinical Neurosciences {\textcopyright} 2019 Japanese Society of Psychiatry and Neurology",
year = "2020",
month = feb,
day = "1",
doi = "10.1111/pcn.12960",
language = "English",
volume = "74",
pages = "132--139",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",
number = "2",
}
