Effectiveness of oseltamivir treatment against influenza type A and type B infection in children

Keiko Mitamura, Norio Sugaya, Mari Nirasawa, Masayoshi Shinjo(H), Yoshinao Takeuchi

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11 Citations (Scopus)

Abstract

We investigated the effectiveness of oseltamivir treatment against influenza virus infection in children. We treated 131 patients (mean age, 5.8 +/- 3.6 years) with oseltamivir (4 mg/kg/day for 5 days) during the 2001-2002 epidemic. All of the patients had been diagnosed with influenza using a rapid diagnosis kit. When treatment was initiated within 48 hours of the onset of fever, 44% of the patients became afebrile (< 37.5 degrees C) within one day, and 86% of them recovered within two days. The average duration of fever after the initiation of oseltamivir treatment was 1.7 days. Oseltamivir was equally effective against both influenza type A and type B. No differences in the effectiveness of oseltamivir treatment were observed between young children (< 4 years of age) and school-aged children (> 6 years of age). No obvious side effects were observed.

Original languageEnglish
Pages (from-to)946-952
Number of pages7
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume76
Issue number11
Publication statusPublished - 2002
Externally publishedYes

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Oseltamivir
Human Influenza
Infection
Virus Diseases
Orthomyxoviridae
Fever
Therapeutics

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Effectiveness of oseltamivir treatment against influenza type A and type B infection in children. / Mitamura, Keiko; Sugaya, Norio; Nirasawa, Mari; Shinjo(H), Masayoshi; Takeuchi, Yoshinao.

In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 76, No. 11, 2002, p. 946-952.

Research output: Contribution to journalArticle

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