TY - JOUR
T1 - Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity
AU - Asano, Teita
AU - Tanaka, Ken ichiro
AU - Suemasu, Shintaro
AU - Ishihara, Tomoaki
AU - Tahara, Kayoko
AU - Suzuki, Toshio
AU - Suzuki, Hidekazu
AU - Fukudo, Shin
AU - Mizushima, Tohru
N1 - Funding Information:
This work was supported by Grants-in-Aid of Scientific Research from the Ministry of Health, Labour, and Welfare of Japan , Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan , and Grants-in-Aid of the Japan Science and Technology Agency .
PY - 2012/4/6
Y1 - 2012/4/6
N2 - Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial. β-(1,3)-d-glucan with β-(1,6) branches (β-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of β-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of β-glucan suppressed the restraint stress- or drug-induced fecal pellet output. β-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that β-glucan could be beneficial for the treatment and prevention of IBS.
AB - Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial. β-(1,3)-d-glucan with β-(1,6) branches (β-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of β-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of β-glucan suppressed the restraint stress- or drug-induced fecal pellet output. β-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that β-glucan could be beneficial for the treatment and prevention of IBS.
KW - Fecal pellet output
KW - Irritable bowel syndrome
KW - Visceral pain response
KW - β-Glucan
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U2 - 10.1016/j.bbrc.2012.03.015
DO - 10.1016/j.bbrc.2012.03.015
M3 - Article
C2 - 22430139
AN - SCOPUS:84862832724
SN - 0006-291X
VL - 420
SP - 444
EP - 449
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -