Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity

Teita Asano, Ken ichiro Tanaka, Shintaro Suemasu, Tomoaki Ishihara, Kayoko Tahara, Toshio Suzuki, Hidekazu Suzuki, Shin Fukudo, Tohru Mizushima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial. β-(1,3)-d-glucan with β-(1,6) branches (β-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of β-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of β-glucan suppressed the restraint stress- or drug-induced fecal pellet output. β-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that β-glucan could be beneficial for the treatment and prevention of IBS.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume420
Issue number2
DOIs
Publication statusPublished - 2012 Apr 6

Fingerprint

Glucans
Irritable Bowel Syndrome
Hypersensitivity
Visceral Pain
Health care
Chronic Pain
Health Care Costs
Abdominal Pain
Habits
Oral Administration
Animals
Animal Models
Therapeutics
Pharmaceutical Preparations
Costs

Keywords

  • β-Glucan
  • Fecal pellet output
  • Irritable bowel syndrome
  • Visceral pain response

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Asano, T., Tanaka, K. I., Suemasu, S., Ishihara, T., Tahara, K., Suzuki, T., ... Mizushima, T. (2012). Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity. Biochemical and Biophysical Research Communications, 420(2), 444-449. https://doi.org/10.1016/j.bbrc.2012.03.015

Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity. / Asano, Teita; Tanaka, Ken ichiro; Suemasu, Shintaro; Ishihara, Tomoaki; Tahara, Kayoko; Suzuki, Toshio; Suzuki, Hidekazu; Fukudo, Shin; Mizushima, Tohru.

In: Biochemical and Biophysical Research Communications, Vol. 420, No. 2, 06.04.2012, p. 444-449.

Research output: Contribution to journalArticle

Asano, T, Tanaka, KI, Suemasu, S, Ishihara, T, Tahara, K, Suzuki, T, Suzuki, H, Fukudo, S & Mizushima, T 2012, 'Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity', Biochemical and Biophysical Research Communications, vol. 420, no. 2, pp. 444-449. https://doi.org/10.1016/j.bbrc.2012.03.015
Asano, Teita ; Tanaka, Ken ichiro ; Suemasu, Shintaro ; Ishihara, Tomoaki ; Tahara, Kayoko ; Suzuki, Toshio ; Suzuki, Hidekazu ; Fukudo, Shin ; Mizushima, Tohru. / Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity. In: Biochemical and Biophysical Research Communications. 2012 ; Vol. 420, No. 2. pp. 444-449.
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