Effects of 17β-estradiol and bisphenol a on the formation of reproductive organs in planarians

Hitoshi Miyashita, Haruka Nakagawa, Kazuya Kobayashi, Motonori Hoshi, Midori Matsumoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Planarians have a remarkable capacity for regeneration after ablation, and they reproduce asexually by fission. However, some planarians can also reproduce and maintain their sexual organs. During the regenerative process, their existing sexual organs degenerate and new ones develop. However, little is known about hormonal regulation during the development of reproductive organs in planarians. In this study, we investigated the effects of 17β-estradiol (a steroid) and bisphenol A (an endocrine disrupter) on the formation of sexual organs in the hermaphroditic planarian Dugesia ryukyuensis. Under control conditions, all worm tissues regenerated into sexual planarians with sexual organs within 4 weeks after ablation. However, in the presence of bisphenol A or 17β-estradiol, although they apparently regenerated into sexual planarians, the yolk glands, which are one of the female sexual organs, failed to regenerate even 7 weeks after ablation. These data suggest that planarians have a steroid hormone system, which plays a key role in the formation and maturation of sexual organs.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalBiological Bulletin
Volume220
Issue number1
Publication statusPublished - 2011 Feb

Fingerprint

Planarians
bisphenol A
estradiol
gonads
Estradiol
Dugesia
endocrine-disrupting chemicals
hormonal regulation
steroid hormones
steroids
Steroids
Sexual Maturation
Regeneration
Hormones

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Effects of 17β-estradiol and bisphenol a on the formation of reproductive organs in planarians. / Miyashita, Hitoshi; Nakagawa, Haruka; Kobayashi, Kazuya; Hoshi, Motonori; Matsumoto, Midori.

In: Biological Bulletin, Vol. 220, No. 1, 02.2011, p. 47-56.

Research output: Contribution to journalArticle

Miyashita, H, Nakagawa, H, Kobayashi, K, Hoshi, M & Matsumoto, M 2011, 'Effects of 17β-estradiol and bisphenol a on the formation of reproductive organs in planarians', Biological Bulletin, vol. 220, no. 1, pp. 47-56.
Miyashita, Hitoshi ; Nakagawa, Haruka ; Kobayashi, Kazuya ; Hoshi, Motonori ; Matsumoto, Midori. / Effects of 17β-estradiol and bisphenol a on the formation of reproductive organs in planarians. In: Biological Bulletin. 2011 ; Vol. 220, No. 1. pp. 47-56.
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