Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

Taiko Oda

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalJournal of Antibiotics
Volume59
Issue number2
DOIs
Publication statusPublished - 2006 Feb

Keywords

  • 2′-demethoxy-2′-propoxygriseofulvin
  • Chinese hamster V79 cells
  • Griseofulvin
  • Microtubule

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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