Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

Taiko Oda

doi:10.1038/ja.2006.17

Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

Taiko Oda

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	Journal of Antibiotics
Volume	59
Issue number	2
DOIs	https://doi.org/10.1038/ja.2006.17
Publication status	Published - 2006 Feb

Keywords

2′-demethoxy-2′-propoxygriseofulvin
Chinese hamster V79 cells
Griseofulvin
Microtubule

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2006.17

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title = "Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells",

abstract = "Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.",

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