Abstract
Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
| Original language | English |
|---|---|
| Pages (from-to) | 114-116 |
| Number of pages | 3 |
| Journal | Journal of Antibiotics |
| Volume | 59 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2006 Feb |
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Keywords
- 2′-demethoxy-2′-propoxygriseofulvin
- Chinese hamster V79 cells
- Griseofulvin
- Microtubule
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells. / Oda, Taiko.
In: Journal of Antibiotics, Vol. 59, No. 2, 02.2006, p. 114-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells
AU - Oda, Taiko
PY - 2006/2
Y1 - 2006/2
N2 - Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
AB - Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
KW - 2′-demethoxy-2′-propoxygriseofulvin
KW - Chinese hamster V79 cells
KW - Griseofulvin
KW - Microtubule
UR - http://www.scopus.com/inward/record.url?scp=33645788034&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645788034&partnerID=8YFLogxK
U2 - 10.1038/ja.2006.17
DO - 10.1038/ja.2006.17
M3 - Article
VL - 59
SP - 114
EP - 116
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 2
ER -