TY - JOUR
T1 - Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells
AU - Oda, Taiko
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2006/2
Y1 - 2006/2
N2 - Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
AB - Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
KW - 2′-demethoxy-2′-propoxygriseofulvin
KW - Chinese hamster V79 cells
KW - Griseofulvin
KW - Microtubule
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U2 - 10.1038/ja.2006.17
DO - 10.1038/ja.2006.17
M3 - Article
C2 - 16629413
AN - SCOPUS:33645788034
VL - 59
SP - 114
EP - 116
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 2
ER -