Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

Shizuko Kobayashi; Minako Kasuya; Yasuo Ishii; Makoto Takehana; Kazuo Sakai; Norio Suzuki; Motokazu Itoi

doi:10.3109/02713689209015081

Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

Shizuko Kobayashi, Minako Kasuya, Yasuo Ishii, Makoto Takehana, Kazuo Sakai, Norio Suzuki, Motokazu Itoi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na⁺/K⁺ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.

Original language	English
Pages (from-to)	1099-1103
Number of pages	5
Journal	Current Eye Research
Volume	11
Issue number	11
DOIs	https://doi.org/10.3109/02713689209015081
Publication status	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats",

abstract = "The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.",

author = "Shizuko Kobayashi and Minako Kasuya and Yasuo Ishii and Makoto Takehana and Kazuo Sakai and Norio Suzuki and Motokazu Itoi",

note = "Funding Information: ACKNOWLEDGMENTS This study was supported by a grant from The Eye Institute for the Cataract Foundation (Tokyo).",

year = "1992",

doi = "10.3109/02713689209015081",

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T1 - Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

AU - Kobayashi, Shizuko

AU - Kasuya, Minako

AU - Ishii, Yasuo

AU - Takehana, Makoto

AU - Sakai, Kazuo

AU - Suzuki, Norio

AU - Itoi, Motokazu

N1 - Funding Information: ACKNOWLEDGMENTS This study was supported by a grant from The Eye Institute for the Cataract Foundation (Tokyo).

PY - 1992

Y1 - 1992

N2 - The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.

AB - The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.

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Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

Abstract

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