Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

Shizuko Kobayashi, Minako Kasuya, Yasuo Ishii, Makoto Takehana, Kazuo Sakai, Norio Suzuki, Motokazu Itoi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.

Original languageEnglish
Pages (from-to)1099-1103
Number of pages5
JournalCurrent Eye Research
Volume11
Issue number11
DOIs
Publication statusPublished - 1992

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Tiopronin
Cataract
X-Rays
Intraperitoneal Injections
Malondialdehyde
Lenses
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Kobayashi, S., Kasuya, M., Ishii, Y., Takehana, M., Sakai, K., Suzuki, N., & Itoi, M. (1992). Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats. Current Eye Research, 11(11), 1099-1103. https://doi.org/10.3109/02713689209015081

Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats. / Kobayashi, Shizuko; Kasuya, Minako; Ishii, Yasuo; Takehana, Makoto; Sakai, Kazuo; Suzuki, Norio; Itoi, Motokazu.

In: Current Eye Research, Vol. 11, No. 11, 1992, p. 1099-1103.

Research output: Contribution to journalArticle

Kobayashi, S, Kasuya, M, Ishii, Y, Takehana, M, Sakai, K, Suzuki, N & Itoi, M 1992, 'Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats', Current Eye Research, vol. 11, no. 11, pp. 1099-1103. https://doi.org/10.3109/02713689209015081
Kobayashi, Shizuko ; Kasuya, Minako ; Ishii, Yasuo ; Takehana, Makoto ; Sakai, Kazuo ; Suzuki, Norio ; Itoi, Motokazu. / Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats. In: Current Eye Research. 1992 ; Vol. 11, No. 11. pp. 1099-1103.
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