Effects of a proton pump inhibitor on the physiological accumulation of fluoro-2-deoxy-D-glucose (FDG) in FDG-positron emission tomography

Yasushi Domeki, Erena Yamazaki, Akira Matsuura, Kazuhiro Kitajima, Koji Murakami, Hiroyuki Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purposes The physiological accumulation of fluoro-2- deoxy-D-glucose (FDG) is common in medical examinations of the digestive tract conducted using FDG-positron emission tomography (PET). The aim of this study was to determine the effects of a proton pump inhibitor (PPI) on the physiological FDG accumulation in the digestive tract. Methods A total of 130 patients examined from July 2007 to October 2008 were included in the final analysis. A PPI was administered orally prior to FDG-PET in 65 patients. The remaining 65 patients underwent FDG-PET without administration of the PPI. The assessments used visual and quantitative evaluations. Results Visual evaluation showed that physiological FDG accumulation in the stomach was significantly reduced (p = 0.037) in the PPI group compared with the control group. The quantitative evaluation also revealed a significant reduction in the maximum standardized uptake values (SUVmax) in the stomach in the PPI group compared with the control group (p<0.0001). Physiological FDG accumulation in the colon showed a decreasing trend on visual evaluation in the PPI group compared with the control group, and the quantitative evaluation found a significant reduction in the physiological FDG accumulation in the colon in the PPI group (p = 0.045). Conclusions The oral administration of a PPI was effective for reducing the physiological accumulation of the FDG in the alimentary tract. However, based on the error associated with SUVmax measurement, a quantitative evaluation should therefore be combined with the visual evaluation.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalSurgery Today
Volume42
Issue number10
DOIs
Publication statusPublished - 2012 Oct
Externally publishedYes

Fingerprint

Proton Pump Inhibitors
Deoxyglucose
Positron-Emission Tomography
Control Groups
Gastrointestinal Tract
Stomach
Colon
Oral Administration

Keywords

  • Colon
  • Physiological accumulation
  • Positron emission tomography
  • Proton pump Inhibitor
  • Stomach

ASJC Scopus subject areas

  • Surgery

Cite this

Effects of a proton pump inhibitor on the physiological accumulation of fluoro-2-deoxy-D-glucose (FDG) in FDG-positron emission tomography. / Domeki, Yasushi; Yamazaki, Erena; Matsuura, Akira; Kitajima, Kazuhiro; Murakami, Koji; Kato, Hiroyuki.

In: Surgery Today, Vol. 42, No. 10, 10.2012, p. 927-933.

Research output: Contribution to journalArticle

Domeki, Yasushi ; Yamazaki, Erena ; Matsuura, Akira ; Kitajima, Kazuhiro ; Murakami, Koji ; Kato, Hiroyuki. / Effects of a proton pump inhibitor on the physiological accumulation of fluoro-2-deoxy-D-glucose (FDG) in FDG-positron emission tomography. In: Surgery Today. 2012 ; Vol. 42, No. 10. pp. 927-933.
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