Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats

Mamoru Tanaka, Michiya Natori, Hitoshi Ishimoto, Kei Miyakoshi, Toyohiko Miyazaki, Toshifumi Kobayashi, Yasunori Yoshimura

Research output: Contribution to journalArticle

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Abstract

We investigated the effects of thromboxane (TX) A2 in rats with ischemia-reperfusion-induced intrauterine growth retardation. A saline solution or OKY-046, a selective TXA2 synthetase inhibitor, was injected into the caudal vein of pregnant rats on gestation day 17 before the induction of 60-min uteroplacental ischemia. The fetuses and placentas were delivered and examined on gestation day 21. Blood from the uterine vein of the occluded horn shortly after uteroplacental ischemia was collected, and plasma concentrations of TXB2 and 6-keto-prostaglandin (PG) F(1α), were determined in the other rats on gestation day 17. Treatment with OKY-046 prevented the ischemia-induced reduction in the fetal body and placental weights, The ratio of 6-keto-PGF(1α), to TXB2 was significantly increased in the OKY-046-treated group. We conclude that the action of TXA2 might play a salient role in our model.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalBiology of the Neonate
Volume72
Issue number3
Publication statusPublished - 1997 Sep

Fingerprint

Thromboxane-A Synthase
Fetal Growth Retardation
Reperfusion
Sprague Dawley Rats
Ischemia
Prostaglandins F
Pregnancy
Veins
Fetal Weight
Thromboxane A2
Ligases
Horns
Sodium Chloride
Placenta
Fetus
ozagrel

Keywords

  • Intrauterine growth retardation
  • Ischemia
  • Prostglandin
  • Reperfusion
  • Thromboxane

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. / Tanaka, Mamoru; Natori, Michiya; Ishimoto, Hitoshi; Miyakoshi, Kei; Miyazaki, Toyohiko; Kobayashi, Toshifumi; Yoshimura, Yasunori.

In: Biology of the Neonate, Vol. 72, No. 3, 09.1997, p. 181-186.

Research output: Contribution to journalArticle

Tanaka, Mamoru ; Natori, Michiya ; Ishimoto, Hitoshi ; Miyakoshi, Kei ; Miyazaki, Toyohiko ; Kobayashi, Toshifumi ; Yoshimura, Yasunori. / Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. In: Biology of the Neonate. 1997 ; Vol. 72, No. 3. pp. 181-186.
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