Effects of ACTH on adrenal angiotensin II receptor subtype expression in vivo

Yudai Kitamura, Hiroyuki Sasamura, Hideaki Nakaya, Tatsuya Maruyama, Matsuhiko Hayashi, Takao Saruta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Control of adrenal aldosterone secretion is an important endocrine mechanism mediated by angiotensin II (Ang. II). Recently three subtypes of angiotensin receptors have been demonstrated in the rat adrenal. Our aim was to examine if these receptors are affected by hormone treatment in vivo. Treatment of rats with ACTH resulted in a decrease in AT2 receptor binding from 766 ± 95 to 310 ± 51 fmol/mg protein (P < 0.05), without significant changes in AT1 receptors. AT2 receptor mRNA was also decreased (18 ± 2% of control, P < 0.05; 25 ± 7% of control, P < 0.05) after both 2 and 7 day treatment with ACTH. Changes in AT1a receptor mRNA or total AT1 mRNA did not reach statistical significance. Moreover, treatment with dexamethasone or aldosterone did not affect AT1a, AT1b, or AT2 mRNA. These results demonstrate that ACTH treatment results in subtype-specific changes in adrenal AT receptor gene expression in vivo.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume146
Issue number1-2
DOIs
Publication statusPublished - 1998 Nov 25

Keywords

  • ACTH
  • Adrenal
  • Aldosterone
  • Angiotensin II
  • Dexamethasone
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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  • Cite this

    Kitamura, Y., Sasamura, H., Nakaya, H., Maruyama, T., Hayashi, M., & Saruta, T. (1998). Effects of ACTH on adrenal angiotensin II receptor subtype expression in vivo. Molecular and Cellular Endocrinology, 146(1-2), 187-195. https://doi.org/10.1016/S0303-7207(98)00158-0