Effects of advanced life support versus basic life support on the mortality rates of patients with trauma in prehospital settings

A study protocol for a systematic review and meta-analysis

Yutaka Kondo, Tatsuma Fukuda, Ryo Uchimido, Toru Hifumi, Kei Hayashida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction Advanced life support (ALS) is thought to be associated with improved survival in prehospital trauma care when compared with basic life support (BLS). However, evidence on the benefits of prehospital ALS for patients with trauma is controversial. Therefore, we aim to clarify if ALS improves mortality in patients with trauma when compared with BLS by conducting a systematic review and meta-analysis of the recent literature. Methods and analysis We will perform searches in PubMed, Embase and the Cochrane Central Register of Controlled Trials for published observational studies, controlled before-and-after studies, randomised controlled trials and other controlled trials conducted in humans and published until March 2017. We will screen search results, assess study selection, extract data and assess the risk of bias in duplicate; disagreements will be resolved through discussions. Data from clinically homogeneous studies will be pooled using a random-effects meta-analysis, heterogeneity of effects will be assessed using the Ï ‡ 2 test of homogeneity, and any observed heterogeneity will be quantified using the I 2 statistic. Last, the Grading of Recommendations Assessment, Development and Evaluation approach will be used to rate the quality of the evidence. Ethics and dissemination Our study does not require ethical approval as it is based on findings of previously published articles. Results will be disseminated through publication in a peer-reviewed journal, presentations at relevant conferences and publications for patient information. Trial registration number PROSPERO (International Prospective Register of Systematic Reviews) registration number CRD42017054389.

Original languageEnglish
Article numbere016912
JournalBMJ open
Volume7
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

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Meta-Analysis
Mortality
Wounds and Injuries
Publications
PubMed
Ethics
Observational Studies
Randomized Controlled Trials
Survival

Keywords

  • advanced life support
  • basic life support
  • first aid
  • resuscitation
  • trauma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of advanced life support versus basic life support on the mortality rates of patients with trauma in prehospital settings : A study protocol for a systematic review and meta-analysis. / Kondo, Yutaka; Fukuda, Tatsuma; Uchimido, Ryo; Hifumi, Toru; Hayashida, Kei.

In: BMJ open, Vol. 7, No. 10, e016912, 01.10.2017.

Research output: Contribution to journalArticle

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