Abstract
Objective We explored whether prior findings of reduction in serotonin 2A receptor (5-HT 2AR) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. Methods We derived 5-HT 2AR nondisplaceable binding potentials (BP ND) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. Results The 5-HT 2AR BP NDs decreased with age, a relationship best described by an exponential-decay regression. The BP NDs were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. Conclusions These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 1300-1308 |
| Number of pages | 9 |
| Journal | International Journal of Geriatric Psychiatry |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2011 Dec |
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Keywords
- [ F]setoperone
- aging
- HRRT
- PET
- PVC
- PVE
- receptor
- serotonin
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Effects of aging on 5-HT 2AR binding : A HRRT PET study with and without partial volume corrections. / Uchida, Hiroyuki; Chow, Tiffany W.; Mamo, David C.; Kapur, Shitij; Mulsant, Benoit H.; Houle, Sylvain; Pollock, Bruce G.; Graff-Guerrero, Ariel.
In: International Journal of Geriatric Psychiatry, Vol. 26, No. 12, 12.2011, p. 1300-1308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of aging on 5-HT 2AR binding
T2 - A HRRT PET study with and without partial volume corrections
AU - Uchida, Hiroyuki
AU - Chow, Tiffany W.
AU - Mamo, David C.
AU - Kapur, Shitij
AU - Mulsant, Benoit H.
AU - Houle, Sylvain
AU - Pollock, Bruce G.
AU - Graff-Guerrero, Ariel
PY - 2011/12
Y1 - 2011/12
N2 - Objective We explored whether prior findings of reduction in serotonin 2A receptor (5-HT 2AR) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. Methods We derived 5-HT 2AR nondisplaceable binding potentials (BP ND) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. Results The 5-HT 2AR BP NDs decreased with age, a relationship best described by an exponential-decay regression. The BP NDs were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. Conclusions These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.
AB - Objective We explored whether prior findings of reduction in serotonin 2A receptor (5-HT 2AR) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. Methods We derived 5-HT 2AR nondisplaceable binding potentials (BP ND) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. Results The 5-HT 2AR BP NDs decreased with age, a relationship best described by an exponential-decay regression. The BP NDs were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. Conclusions These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.
KW - [ F]setoperone
KW - aging
KW - HRRT
KW - PET
KW - PVC
KW - PVE
KW - receptor
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=80855144203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80855144203&partnerID=8YFLogxK
U2 - 10.1002/gps.2682
DO - 10.1002/gps.2682
M3 - Article
C2 - 21351153
AN - SCOPUS:80855144203
VL - 26
SP - 1300
EP - 1308
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 12
ER -