Effects of anion exchange resin as phosphate binder on serum phosphate and iPTH levels in normal rats

Hiroyoshi Inoue, M. Kagoshima, K. Kaibara

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Abstract

In order to investigate the characteristics of anion exchange resins that may safely and effectively bind dietary phosphate in digestive tract, phosphate binding experiments were carried out in vitro and in vivo with normal rats by comparing anion exchange resins, PAA-B (which has the same chemical structure as Sevelamer® HCl) and Dowe 1x8, with CaCO3. In in vitro phosphate binding experiments, PAA-B bound 32.3% less phosphate than CaCO3 at pH 7. In the rat dietary phosphorus excretion experiments, PAA-B, Dowex 1x8, and CaCO3 increased fecal phosphorus excretion by 62.7, 32.3, and 84.0%, respectively. Famotidine significantly reduced the phosphate binding of CaCO3. When phosphate solution was orally administered, PAA-B depressed serum phosphorus augmentations immediately after administration and thereafter effectively depressed serum iPTH. This suggests that anion exchange resins with most primary and secondary amino type anion exchange groups, have bright prospects in the treatment of hyperphosphatemia.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalInternational Journal of Artificial Organs
Volume23
Issue number4
Publication statusPublished - 2000 Apr
Externally publishedYes

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Keywords

  • Anion exchange resin
  • Calcium carbonate
  • Hyperphosphataemia
  • Intact PTH
  • Phosphate

ASJC Scopus subject areas

  • Biophysics

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