Effects of anti-inflammatory drugs on convulsant activity of quinolones: A comparative study of drug interaction between quinolones and anti-inflammatory drugs

Seiji Hori, Junko Kizu, Masahiro Kawamura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Quinolones have been reported to possess potent convulsant activity, which is enhanced when they are administered concurrently with anti-inflammatory drugs. To define the individual drug interactions of quinolones with anti-inflammatory drugs, we studied the convulsant activity of six quinolones with or without 13 anti-inflammatory drugs and 3 analgesic/antipyretic drugs in mice. Intraventricular injections of norfloxacin (NFLX), enoxacin (ENX), ciprofloxacin, lomefloxacin (LFLX), levofloxacin, and gatifloxacin induced convulsions in mice in a dose-dependent manner. Concurrent administration of biphenylacetic acid strongly enhanced the convulsant activity of NFLX, ENX, and LFLX. Flurbiprofen also strongly enhanced the activity of NFLX and ENX, and ketoprofen strongly enhanced the activity of ENX. However, mefenamic acid, piroxicam, tenoxicam, meloxicam, etodolac, sulpyrine, isopropylantipyrine, and acetaminophen had no effect on the convulsant activity of quinolones. These results suggest that each quinolone has an individual drug interaction with each anti-inflammatory drug. It was suggested that we should know which anti-inflammatory drugs enhance the convulsant activity of individual quinolones, and which quinolone has no/weak drug interaction with different anti-inflammatory drugs when these drugs are used concurrently for the treatment of patients with infectious diseases.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume9
Issue number4
DOIs
Publication statusPublished - 2003 Dec

Fingerprint

Convulsants
Quinolones
Drug Interactions
Enoxacin
Anti-Inflammatory Agents
Norfloxacin
Pharmaceutical Preparations
meloxicam
tenoxicam
Etodolac
Mefenamic Acid
Dipyrone
Intraventricular Injections
Flurbiprofen
Piroxicam
Ketoprofen
Antipyretics
Levofloxacin
Acetaminophen
Ciprofloxacin

Keywords

  • Anti-inflammatory drugs
  • Convulsion
  • Drug interaction
  • Quinolones

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Effects of anti-inflammatory drugs on convulsant activity of quinolones : A comparative study of drug interaction between quinolones and anti-inflammatory drugs. / Hori, Seiji; Kizu, Junko; Kawamura, Masahiro.

In: Journal of Infection and Chemotherapy, Vol. 9, No. 4, 12.2003, p. 314-320.

Research output: Contribution to journalArticle

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