[Effects of carteolol hydrochloride on experimental choroidal neovascularization].

Susumu Ishida, Hiroshi Mochimaru, Norihiro Nagai, Kousuke Noda, Yoko Ozawa

Research output: Contribution to journalArticle

Abstract

To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV). Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay. Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha. Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalNippon Ganka Gakkai zasshi
Volume115
Issue number4
Publication statusPublished - 2011 Apr

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Ishida, S., Mochimaru, H., Nagai, N., Noda, K., & Ozawa, Y. (2011). [Effects of carteolol hydrochloride on experimental choroidal neovascularization]. Nippon Ganka Gakkai zasshi, 115(4), 355-361.