[Effects of carteolol hydrochloride on experimental choroidal neovascularization].

Susumu Ishida, Hiroshi Mochimaru, Norihiro Nagai, Kousuke Noda, Yoko Ozawa

Research output: Contribution to journalArticle

Abstract

To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV). Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay. Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha. Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalNippon Ganka Gakkai zasshi
Volume115
Issue number4
Publication statusPublished - 2011 Apr
Externally publishedYes

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Carteolol
Choroidal Neovascularization
Choroid
Retinal Pigment Epithelium
Chemokine CCL2
Intercellular Adhesion Molecule-1
Tumor Necrosis Factor-alpha
Macrophages
Light Coagulation
Fluorescein
Lectins
Lasers
Anti-Inflammatory Agents
Enzyme-Linked Immunosorbent Assay
Staining and Labeling

ASJC Scopus subject areas

  • Ophthalmology

Cite this

[Effects of carteolol hydrochloride on experimental choroidal neovascularization]. / Ishida, Susumu; Mochimaru, Hiroshi; Nagai, Norihiro; Noda, Kousuke; Ozawa, Yoko.

In: Nippon Ganka Gakkai zasshi, Vol. 115, No. 4, 04.2011, p. 355-361.

Research output: Contribution to journalArticle

Ishida, Susumu ; Mochimaru, Hiroshi ; Nagai, Norihiro ; Noda, Kousuke ; Ozawa, Yoko. / [Effects of carteolol hydrochloride on experimental choroidal neovascularization]. In: Nippon Ganka Gakkai zasshi. 2011 ; Vol. 115, No. 4. pp. 355-361.
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