Effects of chalcone derivatives on lipoxygenase and cyclooxygenase activities of mouse epidermis

Teruo Nakadate, Eriko Aizu, Satoshi Yamamoto, Ryuichi Kato

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The effects of chalcone derivatives on 12-lipoxygenase and cyclooxygenase of mouse epidermis were investigated. The chalcone derivatives which have 3,4-dihydroxycinnamoyl structure in the molecule, such as 3,4-dihydroxychalcone, 3,4,2′-trihydroxychalcone, 3,4,4′-trihydroxychalcone and 3,4,2′4′-tetrahydroxychalcone, potently inhibited epidermal 12-lipoxygenase activity. Although some of them also inhibited cyclooxygenase activity at relatively high concentrations, the inhibitory effects of these chalcone derivatives on 12-lipoxygenase were 10 times or more potent than their effects on cyclooxygenase. The chalcone derivatives which have cinnamoyl or 4-hydroxycinnamoyl structure, instead of 3,4-dihydroxycinnamoyl structure, in the molecule, showed little or no inhibitory effects on either 12-lipoxygenase or cyclooxygenase activities. The inhibitory effects of chalcone derivatives on 12-lipoxygenase and cyclooxygenase of mouse epidermis are dependent on the particular structure, i.e. 3,4-dihydroxycinnamoyl structure, of the chalcone derivatives.

Original languageEnglish
Pages (from-to)357-368
Number of pages12
JournalProstaglandins
Volume30
Issue number3
DOIs
Publication statusPublished - 1985 Sep

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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