Effects of Constant Intake of Lutein-rich Spinach on Macular Pigment Optical Density: a Pilot Study

Yoko Ozawa, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Hajime Shinoda, Mitsuru Watanabe, Kazuo Tsubota

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3 Citations (Scopus)


RESULTS: Mean lutein ± SD intake from food was 0.87 ± 0.76 mg/1,000 kcal at baseline. Mean MPOD, best corrected visual acuity, and serum lutein concentrations were increased at 1 and 2 months compared with baseline.

CONCLUSION: Constant intake of lutein-rich spinach increased both MPOD and serum lutein concentrations. These data are important for planning of a future interventional study examining the effects of dietary lutein.

PURPOSE: Anti-oxidative nutrient supplements, including lutein, are an important preventive approach for age-related macular degeneration (AMD). In this pilot study, we obtained data required for planning a future dietary intervention study investigating the prevention of AMD progression with lutein-rich spinach.

METHODS: We examined 22 eyes from 11 healthy nonsmokers (ages 21-45 years) who ingested 75 g of frozen spinach containing 10 mg lutein every day for 2 months. Food frequency questionnaire, measurement of macular pigment optical density (MPOD), and eye and blood examinations were performed.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalNippon Ganka Gakkai zasshi
Issue number1
Publication statusPublished - 2016 Jan 1


ASJC Scopus subject areas

  • Medicine(all)

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