Effects of diclofenac eye drops on corneal epithelial structure and function after small-incision cataract surgery

J. Shimazaki, H. Fujishima, Y. Yagi, Kazuo Tsubota

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To investigate prospectively the effect of diclofenac sodium (DfNa) eye drops on corneal epithelial structure and function. Methods: Seventeen patients with bilateral age-related cataract undergoing phacoemulsification combined with intraocular lens implantation were studied prospectively. After the surgery on both eyes, one eye each of these patients was assigned randomly to receive 0.1% DfNa eye drops three times daily (DfNa group), and the other eye served as control (control group). Vital stainings, tear function test, corneal sensitivity measurement, specular microscopy for corneal epithelium and endothelium, pachymetry, anterior fluorometry to measure epithelial barrier function, and laser flare-cell-metry were performed before and after surgery. Results: There were no statistically significant differences between the DfNa and control groups in any measurement examined except for laser cell-flare-metry, in which the DfNa group demonstrated a significantly lower flare value at day 7 postoperatively (compare with the preoperative level of 73% ± 41% in the DfNa group, and 130% ± 98% in the control group, P = 0.035). Epithelial cells in the DfNa group showed slight elongation and increased permeability postoperatively; however, there were no statistically significant differences with the control group. Conclusions: Administration of DfNa eye drops did not cause significant abnormalities in the corneal epithelial structure or function of patients who had undergone small-incision cataract surgery. Their safety for use in procedures such as excimer laser photorefractive keratectomy remains to be established.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalOphthalmology
Volume103
Issue number1
Publication statusPublished - 1996
Externally publishedYes

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Ophthalmic Solutions
Diclofenac
Cataract
Control Groups
Lasers
Laser Corneal Surgery
Photorefractive Keratectomy
Corneal Endothelium
Fluorometry
Excimer Lasers
Corneal Epithelium
Intraocular Lens Implantation
Phacoemulsification
Tears
Microscopy
Permeability
Epithelial Cells
Staining and Labeling
Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effects of diclofenac eye drops on corneal epithelial structure and function after small-incision cataract surgery. / Shimazaki, J.; Fujishima, H.; Yagi, Y.; Tsubota, Kazuo.

In: Ophthalmology, Vol. 103, No. 1, 1996, p. 50-57.

Research output: Contribution to journalArticle

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