Effects of exercise and dietary therapies on renal function and morphological findings in the kidney and glucose-fatty metabolism in OLETF rats - Use of OLETF rats as a model of type II diabetes mellitus -

Masato Suzuki, Noriko Hodumi, Masaki Kimura, Masayuki Nakaya, Touko Shimizu, Tadashi Takao, Tadao Magara, Yutaka Mori, Katsuhiko Machida

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2 Citations (Scopus)

Abstract

The effects of exercise and dietary therapy on the prevention of diabetic nephropathy (DN) were compared. Thirty-two male OLETF rats were divided into four groups (Ex, Diet, Sed, Pre). Fourteen LETO rats served as the normal controls. Therapy was conducted for 10 weeks from age 22 to 31 weeks. The Ex group was trained by voluntary exercise, and the Diet group had a restricted food intake resulting in the same BW as that of the Ex group. The Ex developed a significant increase in urinary albumin excretion compared to the Diet group, although significantly less than the Sed group. Blood pressure in the Ex group showed a tendency to be higher during therapy. BW and serum lipids were significantly reduced, and glucose intolerance was improved in both the Ex and Diet groups. There were no differences in the metabolic indices between the Ex and Diet groups. The Ex group showed a significantly heavier kidney weight and a tendency for enlargement of the glomerular area and volume. The protective effect of DN through improvement of the metabolic disorder by exercise might be offset by exercise-induced renal loads. Control of exercise intensity and blood pressure appear to be important as well as the improvement of glucose intolerance and lipid metabolisms in exercise therapy to prevent an occurrence and development of DN.

Original languageEnglish
Pages (from-to)403-418
Number of pages16
JournalJapanese Journal of Physical Fitness and Sports Medicine
Volume49
Issue number3
Publication statusPublished - 2000 Jun

Keywords

  • Dietary therapy
  • Exercise therapy
  • Glucose intolerance
  • OLETF rats
  • Urinary albumin

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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