TY - JOUR
T1 - Effects of exercise on residual renal function in patients undergoing peritoneal dialysis
T2 - A post-hoc analysis of a randomized controlled trial
AU - Uchiyama, Kiyotaka
AU - Washida, Naoki
AU - Morimoto, Kohkichi
AU - Muraoka, Kaori
AU - Nakayama, Takashin
AU - Adachi, Keika
AU - Kasai, Takahiro
AU - Miyashita, Kazutoshi
AU - Wakino, Shu
AU - Itoh, Hiroshi
N1 - Publisher Copyright:
© 2020 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy
PY - 2020/12
Y1 - 2020/12
N2 - We aimed to investigate the effects of exercise on renal outcomes in patients undergoing peritoneal dialysis (PD). In a post-hoc analysis of a randomized controlled trial of a 12-week home-based exercise program involving 47 patients undergoing PD, we excluded 18 patients with anuria and analyzed 13 and 16 patients in the usual care and exercise groups, respectively. The primary outcomes were weekly renal creatinine clearance (CCr) and urinary biomarkers: liver-type fatty acid-binding protein (L-FABP) and the microalbumin-to-creatinine ratio (ACR). Although the maintenance of weekly renal CCr in the exercise group was not significantly different compared with that in the usual care group (P =.09), urinary L-FABP levels (P =.02) and ACR (P =.04) were significantly decreased in the exercise group. To the best of our knowledge, this is the first study to demonstrate the beneficial effects of exercise on renal outcomes in patients undergoing PD.
AB - We aimed to investigate the effects of exercise on renal outcomes in patients undergoing peritoneal dialysis (PD). In a post-hoc analysis of a randomized controlled trial of a 12-week home-based exercise program involving 47 patients undergoing PD, we excluded 18 patients with anuria and analyzed 13 and 16 patients in the usual care and exercise groups, respectively. The primary outcomes were weekly renal creatinine clearance (CCr) and urinary biomarkers: liver-type fatty acid-binding protein (L-FABP) and the microalbumin-to-creatinine ratio (ACR). Although the maintenance of weekly renal CCr in the exercise group was not significantly different compared with that in the usual care group (P =.09), urinary L-FABP levels (P =.02) and ACR (P =.04) were significantly decreased in the exercise group. To the best of our knowledge, this is the first study to demonstrate the beneficial effects of exercise on renal outcomes in patients undergoing PD.
KW - exercise
KW - liver-type fatty acid-binding protein
KW - microalbumin-to-creatinine ratio
KW - peritoneal dialysis
KW - residual renal function
UR - http://www.scopus.com/inward/record.url?scp=85081250404&partnerID=8YFLogxK
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U2 - 10.1111/1744-9987.13481
DO - 10.1111/1744-9987.13481
M3 - Article
C2 - 31997526
AN - SCOPUS:85081250404
SN - 1744-9979
VL - 24
SP - 668
EP - 676
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
IS - 6
ER -