Effects of family history on inflammatory bowel disease characteristics in Japanese patients

Erika Kuwahara, Keiko Asakura, Yuji Nishiwaki, Nagamu Inoue, Mamoru Watanabe, Toshifumi Hibi, Toru Takebayashi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background Although the prevalence of inflammatory bowel disease (IBD) is reported to have reached a plateau in Western countries, it is increasing in Asia. The etiology of IBD is still under investigation. We performed an epidemiological study to clarify the characteristics of IBD in Japan, focusing on patients' family history. Methods We obtained clinical data on ulcerative colitis (UC) (46,114 cases) and Crohn's disease (CD) (11,305 cases) in 2007 from an electronic database maintained under the Japanese Ministry of Health, Labour and Welfarés nationwide registry system, and analyzed the differences in disease characteristics between patients with IBD who had a family history of the disease and those who did not. Results A total of 2.7% of the patients with UC and 2.6% of those with CD had a family history. The present age and age at disease onset were lower among the patients with UC who had a family history than among those without (present age: p\0.001; age at disease onset: p\0.001; Mann-Whitney U-test), but no similar trend was observed in the patients with CD. Disease severity was worse among both the UC and CD patients with a family history. The clinical course of patients with UC was not affected by family history. Levels of independence in daily life were associated with family history among CD patients, whereas age was associated with levels of independence in daily life among UC patients. Conclusion Disease characteristics of IBD vary in some aspects according to the presence or absence of a family history.

Original languageEnglish
Pages (from-to)961-968
Number of pages8
JournalJournal of Gastroenterology
Volume47
Issue number9
DOIs
Publication statusPublished - 2012 Sep

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Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Age of Onset
Nonparametric Statistics
Registries
Epidemiologic Studies
Japan
Databases
Health

Keywords

  • Family history
  • Inflammatory bowel disease
  • Japan

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of family history on inflammatory bowel disease characteristics in Japanese patients. / Kuwahara, Erika; Asakura, Keiko; Nishiwaki, Yuji; Inoue, Nagamu; Watanabe, Mamoru; Hibi, Toshifumi; Takebayashi, Toru.

In: Journal of Gastroenterology, Vol. 47, No. 9, 09.2012, p. 961-968.

Research output: Contribution to journalArticle

Kuwahara, Erika ; Asakura, Keiko ; Nishiwaki, Yuji ; Inoue, Nagamu ; Watanabe, Mamoru ; Hibi, Toshifumi ; Takebayashi, Toru. / Effects of family history on inflammatory bowel disease characteristics in Japanese patients. In: Journal of Gastroenterology. 2012 ; Vol. 47, No. 9. pp. 961-968.
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abstract = "Background Although the prevalence of inflammatory bowel disease (IBD) is reported to have reached a plateau in Western countries, it is increasing in Asia. The etiology of IBD is still under investigation. We performed an epidemiological study to clarify the characteristics of IBD in Japan, focusing on patients' family history. Methods We obtained clinical data on ulcerative colitis (UC) (46,114 cases) and Crohn's disease (CD) (11,305 cases) in 2007 from an electronic database maintained under the Japanese Ministry of Health, Labour and Welfar{\'e}s nationwide registry system, and analyzed the differences in disease characteristics between patients with IBD who had a family history of the disease and those who did not. Results A total of 2.7{\%} of the patients with UC and 2.6{\%} of those with CD had a family history. The present age and age at disease onset were lower among the patients with UC who had a family history than among those without (present age: p\0.001; age at disease onset: p\0.001; Mann-Whitney U-test), but no similar trend was observed in the patients with CD. Disease severity was worse among both the UC and CD patients with a family history. The clinical course of patients with UC was not affected by family history. Levels of independence in daily life were associated with family history among CD patients, whereas age was associated with levels of independence in daily life among UC patients. Conclusion Disease characteristics of IBD vary in some aspects according to the presence or absence of a family history.",
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