Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Hideko Kanazawa, Teruo Okano

Research output: Contribution to conferencePaper

Abstract

We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Bioactive compounds
  • Chromatography
  • Graft density
  • Living radical polymerization
  • Thermoresponsive surfaces

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces'. Together they form a unique fingerprint.

  • Cite this

    Nagase, K., Kobayashi, J., Kikuchi, A., Kanazawa, H., & Okano, T. (2006). Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.