Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Kenichi Nagase; Jun Kobayashi; Akihiko Kikuchi; Hideko Kanazawa; Teruo Okano

Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Hideko Kanazawa, Teruo Okano

Research output: Contribution to conference › Paper › peer-review

Abstract

We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.

Original language	English
Number of pages	1
Publication status	Published - 2006 Oct 19
Externally published	Yes
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Other

Other	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Bioactive compounds
Chromatography
Graft density
Living radical polymerization
Thermoresponsive surfaces

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces",

abstract = "We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.",

keywords = "Bioactive compounds, Chromatography, Graft density, Living radical polymerization, Thermoresponsive surfaces",

author = "Kenichi Nagase and Jun Kobayashi and Akihiko Kikuchi and Hideko Kanazawa and Teruo Okano",

year = "2006",

month = oct,

day = "19",

language = "English",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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TY - CONF

T1 - Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

AU - Nagase, Kenichi

AU - Kobayashi, Jun

AU - Kikuchi, Akihiko

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.

AB - We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.

KW - Bioactive compounds

KW - Chromatography

KW - Graft density

KW - Living radical polymerization

KW - Thermoresponsive surfaces

UR - http://www.scopus.com/inward/record.url?scp=33749830946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749830946&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749830946

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Abstract

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Keywords

ASJC Scopus subject areas

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