Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Hideko Kanazawa, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages1980
Number of pages1
Volume55
Edition1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Fingerprint

Chain length
Grafts
Polymers
Atom transfer radical polymerization
Brushes
Silica
Temperature

Keywords

  • Bioactive compounds
  • Chromatography
  • Graft density
  • Living radical polymerization
  • Thermoresponsive surfaces

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces. / Nagase, Kenichi; Kobayashi, Jun; Kikuchi, Akihiko; Kanazawa, Hideko; Okano, Teruo.

Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 1980.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nagase, K, Kobayashi, J, Kikuchi, A, Kanazawa, H & Okano, T 2006, Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces. in Polymer Preprints, Japan. 1 edn, vol. 55, pp. 1980, 55th SPSJ Annual Meeting, Nagoya, Japan, 06/5/24.
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