Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men

Tetsuya Ohira, Takeshi Tanigawa, Minako Tabata, Hironori Imano, Akihiko Kitamura, Masahiko Kiyama, Shinichi Sato, Tomonori Okamura, Renzhe Cui, Kazuko A. Koike, Takashi Shimamoto, Hiroyasu Iso

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

We sought to examine effects of habitual alcohol intake on ambulatory blood pressure (BP), heart rate (HR), and HR variability among Japanese men. Subjects were 539 men aged 35 to 65 years from rural and urban communities. Ambulatory BP and HR were monitored with an automated, portable, noninvasive multibiomedical recorder. Power spectral analysis of the RR intervals on the ECG was performed every 5 minutes. Compared with nondrinkers, moderate drinkers (alcohol intake 23 to 45 g/d) and heavy drinkers (alcohol intake ≥46 g/d) showed higher age- and field-adjusted mean values of systolic and diastolic BPs during the morning and while awake, but there were no differences in BPs over 24-hour periods and while asleep among the alcohol intake categories. Alcohol intake was positively associated with mean values of sleep-morning differences and daytime variability in BPs, HRs while awake and asleep, and low frequency: high frequency ratio while asleep. The results were virtually unchanged after adjustment for body mass index, smoking, and diabetes mellitus. Compared with the nondrinkers, age- and field-adjusted odds ratios of the morning BP surge (excess elevation of BP in the morning: morning systolic BP minus sleep systolic BP ≥37 mm Hg) for light (alcohol intake 0 to 22 g/d), moderate, and heavy drinkers were 0.96 (95% CI: 0.34 to 2.78), 1.68 (95% CI: 0.64 to 4.38), and 2.73 (95% CI: 1.12 to 6.67), respectively. Habitual alcohol intake was associated with increased BP in the morning, HR while awake and asleep, and sympathetic activity while asleep, which may explain some of the mechanisms of the relationship between heavy alcohol intake and risk of cardiovascular diseases.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalHypertension
Volume53
Issue number1
DOIs
Publication statusPublished - 2009 Jan
Externally publishedYes

Fingerprint

Heart Rate
Alcohols
Blood Pressure
Sleep
Rural Population
Diabetes Mellitus
Electrocardiography
Body Mass Index
Cardiovascular Diseases
Smoking
Odds Ratio
Light

Keywords

  • Alcohol intake
  • Ambulatory blood pressure monitoring
  • Autonomic nerve function
  • Heart rate variability
  • Population-based

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men. / Ohira, Tetsuya; Tanigawa, Takeshi; Tabata, Minako; Imano, Hironori; Kitamura, Akihiko; Kiyama, Masahiko; Sato, Shinichi; Okamura, Tomonori; Cui, Renzhe; Koike, Kazuko A.; Shimamoto, Takashi; Iso, Hiroyasu.

In: Hypertension, Vol. 53, No. 1, 01.2009, p. 13-19.

Research output: Contribution to journalArticle

Ohira, T, Tanigawa, T, Tabata, M, Imano, H, Kitamura, A, Kiyama, M, Sato, S, Okamura, T, Cui, R, Koike, KA, Shimamoto, T & Iso, H 2009, 'Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men', Hypertension, vol. 53, no. 1, pp. 13-19. https://doi.org/10.1161/HYPERTENSIONAHA.108.114835
Ohira, Tetsuya ; Tanigawa, Takeshi ; Tabata, Minako ; Imano, Hironori ; Kitamura, Akihiko ; Kiyama, Masahiko ; Sato, Shinichi ; Okamura, Tomonori ; Cui, Renzhe ; Koike, Kazuko A. ; Shimamoto, Takashi ; Iso, Hiroyasu. / Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men. In: Hypertension. 2009 ; Vol. 53, No. 1. pp. 13-19.
@article{4a0330b253064f87920e1ada6b667bf2,
title = "Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men",
abstract = "We sought to examine effects of habitual alcohol intake on ambulatory blood pressure (BP), heart rate (HR), and HR variability among Japanese men. Subjects were 539 men aged 35 to 65 years from rural and urban communities. Ambulatory BP and HR were monitored with an automated, portable, noninvasive multibiomedical recorder. Power spectral analysis of the RR intervals on the ECG was performed every 5 minutes. Compared with nondrinkers, moderate drinkers (alcohol intake 23 to 45 g/d) and heavy drinkers (alcohol intake ≥46 g/d) showed higher age- and field-adjusted mean values of systolic and diastolic BPs during the morning and while awake, but there were no differences in BPs over 24-hour periods and while asleep among the alcohol intake categories. Alcohol intake was positively associated with mean values of sleep-morning differences and daytime variability in BPs, HRs while awake and asleep, and low frequency: high frequency ratio while asleep. The results were virtually unchanged after adjustment for body mass index, smoking, and diabetes mellitus. Compared with the nondrinkers, age- and field-adjusted odds ratios of the morning BP surge (excess elevation of BP in the morning: morning systolic BP minus sleep systolic BP ≥37 mm Hg) for light (alcohol intake 0 to 22 g/d), moderate, and heavy drinkers were 0.96 (95{\%} CI: 0.34 to 2.78), 1.68 (95{\%} CI: 0.64 to 4.38), and 2.73 (95{\%} CI: 1.12 to 6.67), respectively. Habitual alcohol intake was associated with increased BP in the morning, HR while awake and asleep, and sympathetic activity while asleep, which may explain some of the mechanisms of the relationship between heavy alcohol intake and risk of cardiovascular diseases.",
keywords = "Alcohol intake, Ambulatory blood pressure monitoring, Autonomic nerve function, Heart rate variability, Population-based",
author = "Tetsuya Ohira and Takeshi Tanigawa and Minako Tabata and Hironori Imano and Akihiko Kitamura and Masahiko Kiyama and Shinichi Sato and Tomonori Okamura and Renzhe Cui and Koike, {Kazuko A.} and Takashi Shimamoto and Hiroyasu Iso",
year = "2009",
month = "1",
doi = "10.1161/HYPERTENSIONAHA.108.114835",
language = "English",
volume = "53",
pages = "13--19",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Effects of habitual alcohol intake on ambulatory blood pressure, heart rate, and its variability among japanese men

AU - Ohira, Tetsuya

AU - Tanigawa, Takeshi

AU - Tabata, Minako

AU - Imano, Hironori

AU - Kitamura, Akihiko

AU - Kiyama, Masahiko

AU - Sato, Shinichi

AU - Okamura, Tomonori

AU - Cui, Renzhe

AU - Koike, Kazuko A.

AU - Shimamoto, Takashi

AU - Iso, Hiroyasu

PY - 2009/1

Y1 - 2009/1

N2 - We sought to examine effects of habitual alcohol intake on ambulatory blood pressure (BP), heart rate (HR), and HR variability among Japanese men. Subjects were 539 men aged 35 to 65 years from rural and urban communities. Ambulatory BP and HR were monitored with an automated, portable, noninvasive multibiomedical recorder. Power spectral analysis of the RR intervals on the ECG was performed every 5 minutes. Compared with nondrinkers, moderate drinkers (alcohol intake 23 to 45 g/d) and heavy drinkers (alcohol intake ≥46 g/d) showed higher age- and field-adjusted mean values of systolic and diastolic BPs during the morning and while awake, but there were no differences in BPs over 24-hour periods and while asleep among the alcohol intake categories. Alcohol intake was positively associated with mean values of sleep-morning differences and daytime variability in BPs, HRs while awake and asleep, and low frequency: high frequency ratio while asleep. The results were virtually unchanged after adjustment for body mass index, smoking, and diabetes mellitus. Compared with the nondrinkers, age- and field-adjusted odds ratios of the morning BP surge (excess elevation of BP in the morning: morning systolic BP minus sleep systolic BP ≥37 mm Hg) for light (alcohol intake 0 to 22 g/d), moderate, and heavy drinkers were 0.96 (95% CI: 0.34 to 2.78), 1.68 (95% CI: 0.64 to 4.38), and 2.73 (95% CI: 1.12 to 6.67), respectively. Habitual alcohol intake was associated with increased BP in the morning, HR while awake and asleep, and sympathetic activity while asleep, which may explain some of the mechanisms of the relationship between heavy alcohol intake and risk of cardiovascular diseases.

AB - We sought to examine effects of habitual alcohol intake on ambulatory blood pressure (BP), heart rate (HR), and HR variability among Japanese men. Subjects were 539 men aged 35 to 65 years from rural and urban communities. Ambulatory BP and HR were monitored with an automated, portable, noninvasive multibiomedical recorder. Power spectral analysis of the RR intervals on the ECG was performed every 5 minutes. Compared with nondrinkers, moderate drinkers (alcohol intake 23 to 45 g/d) and heavy drinkers (alcohol intake ≥46 g/d) showed higher age- and field-adjusted mean values of systolic and diastolic BPs during the morning and while awake, but there were no differences in BPs over 24-hour periods and while asleep among the alcohol intake categories. Alcohol intake was positively associated with mean values of sleep-morning differences and daytime variability in BPs, HRs while awake and asleep, and low frequency: high frequency ratio while asleep. The results were virtually unchanged after adjustment for body mass index, smoking, and diabetes mellitus. Compared with the nondrinkers, age- and field-adjusted odds ratios of the morning BP surge (excess elevation of BP in the morning: morning systolic BP minus sleep systolic BP ≥37 mm Hg) for light (alcohol intake 0 to 22 g/d), moderate, and heavy drinkers were 0.96 (95% CI: 0.34 to 2.78), 1.68 (95% CI: 0.64 to 4.38), and 2.73 (95% CI: 1.12 to 6.67), respectively. Habitual alcohol intake was associated with increased BP in the morning, HR while awake and asleep, and sympathetic activity while asleep, which may explain some of the mechanisms of the relationship between heavy alcohol intake and risk of cardiovascular diseases.

KW - Alcohol intake

KW - Ambulatory blood pressure monitoring

KW - Autonomic nerve function

KW - Heart rate variability

KW - Population-based

UR - http://www.scopus.com/inward/record.url?scp=58149395043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149395043&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.108.114835

DO - 10.1161/HYPERTENSIONAHA.108.114835

M3 - Article

VL - 53

SP - 13

EP - 19

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 1

ER -