Effects of high glucose and lipotoxicity on diabetic podocytes

Ran Nakamichi, Kaori Hayashi, Hiroshi Itoh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Glomerular podocytes are highly differentiated cells that cover glomerular capillaries from the outside and have a characteristic morphology with numerous foot processes. The formation of slit membranes between the foot processes serves as a final filtration barrier for urine filtration from the blood. Podocyte damage causes disruption of the slit membrane, subsequent proteinuria and finally glomerulosclerosis, which is a common pathway in various types of chronic kidney disease (CKD). In recent years, there has been an increase in diabetes, due to rapid lifestyle changes, which is the main cause of CKD. Therefore, understanding the effect of diabetic status on podocytes is of great importance to establish a strategy for preventing CKD progression. In this review, we summarize altered glucose and lipid metabolism in diabetic podocytes and also discuss the reversibility of the changes in podocyte phenotype.

Original languageEnglish
Article number241
Pages (from-to)1-11
Number of pages11
JournalNutrients
Volume13
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Keywords

  • Diabetic nephropathy
  • High glucose
  • Lipotoxicity
  • Podocyte

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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