Effects of high linear energy transfer radiation on the cochlea of C3H/He mouse during postnatal developmental course

Yumiko Nitta, Nobukazu Araki, Kohsaku Nitta, Toshihide Harada, Fumiko Ishizaki, Jyukou Andou

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate the biological effectiveness of neutrons at energies below 1MeV with regard to ear toxicity, we exposed mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or 137Cs gamma rays at 7 days of age, and observed subsequent morphological changes in the inner ear with light and scanning electron microscopes. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti showed degeneration around 6 hours and disappeared by 72 hours post-irradiation. The apoptotic cell death of the epithelium of the greater epithelial ridge was inducible by the radiation at 3 or 4 days of age. The hair cells formed the protrusion structures of the surface by 72 hours post-irradiation. Neutron-irradiation also caused acute otitis media until 10 weeks of age.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalJournal of Radiation Research
Volume46
Issue number1
DOIs
Publication statusPublished - 2005 Mar

Fingerprint

Linear Energy Transfer
cochlea
linear energy transfer (LET)
Inbred C3H Mouse
Cochlea
Neutrons
ear
energy transfer
mice
epithelium
Radiation
neutrons
ears
irradiation
ridges
Gamma Rays
radiation
gamma rays
gamma radiation
Ear

Keywords

  • Cochlear degeneration
  • High linear energy transfer radiation
  • Mouse
  • Neutron
  • SEM

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Effects of high linear energy transfer radiation on the cochlea of C3H/He mouse during postnatal developmental course. / Nitta, Yumiko; Araki, Nobukazu; Nitta, Kohsaku; Harada, Toshihide; Ishizaki, Fumiko; Andou, Jyukou.

In: Journal of Radiation Research, Vol. 46, No. 1, 03.2005, p. 75-81.

Research output: Contribution to journalArticle

Nitta, Yumiko ; Araki, Nobukazu ; Nitta, Kohsaku ; Harada, Toshihide ; Ishizaki, Fumiko ; Andou, Jyukou. / Effects of high linear energy transfer radiation on the cochlea of C3H/He mouse during postnatal developmental course. In: Journal of Radiation Research. 2005 ; Vol. 46, No. 1. pp. 75-81.
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