TY - JOUR
T1 - Effects of interaction between varus thrust and ambulatory physical activity on knee pain in individuals with knee osteoarthritis
T2 - an exploratory study with 12-month follow-up
AU - Iijima, Hirotaka
AU - Aoyama, Tomoki
AU - Eguchi, Ryo
AU - Takahashi, Masaki
AU - Matsuda, Shuichi
N1 - Funding Information:
Funding This work was supported in part by a Grant-in-Aid from the Japan Society for the Promotion of Science (https://www.jsps.go.jp/) for Scientific Research (grant no. 16dk0110007h0003) and for Research Fellows to HI.
Funding Information:
The authors also thank Dr. Naoto Fukutani (Kyoto University, Kyoto) for assistance in data collection and data analysis. The authors also thank Dr. Eishi Kaneda, Ms. Yuko Yamamoto, Mr. Masakazu Hiraoka, Mr. Kazuyuki Miyanobu, and Mr. Masashi Jinnouchi (Nozomi Orthopedic Clinic, Hiroshima) for assistance and advice. We would like to thank Editage (www.editage.jp) for English language editing. The authors did not receive any financial support or other benefits from commercial sources for the work reported in the manuscript. There are no potential conflicts of interest related to this work.
Publisher Copyright:
© 2019, International League of Associations for Rheumatology (ILAR).
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Introduction: This study aimed to examine the interaction effect between ambulatory physical activity (PA) and varus thrust on knee pain in individuals with knee osteoarthritis (OA). Method: Subjects (n = 207; mean age: 73.1 years, 71.5% women) in orthopedic clinics with diagnosed knee OA (Kellgren/Lawrence grade ≥ 1) were enrolled in this 12-month observational cohort study. Participants underwent gait observation for varus thrust assessment and pedometer-based ambulatory PA measurements at baseline and 12-month follow-up. Knee pain intensity was assessed using the Japanese Knee Osteoarthritis Measure pain subscale as a primary outcome measure. Multiple linear regression analyses were performed to evaluate ambulatory PA–thrust interaction on knee pain intensity. Results: Ninety-two subjects (mean age, 73.4 years; 68.5% women) completed the 12-month follow-up assessment. Baseline ambulatory PA–thrust interaction was significant (P = 0.017) in the cross-sectional analysis, adjusting for covariates, which yielded R2 = 0.310. Subgroup analysis showed that varus thrust was significantly associated with worse knee pain in subjects walking ≥ 5000 steps/day adjusting for covariates (beta: 7.94; 95% CI: 3.82, 12.1; P < 0.001) with a higher predictive ability (R2 = 0.664). In contrast, ambulatory PA–thrust interaction in the longitudinal analysis showed no significant association with knee pain changes. Conclusions: Ambulatory PA interacted with varus thrust in the association with knee pain, as coexisting high ambulatory PA and varus thrust had the strongest association with higher knee pain. Maximal pain relief effects might be achieved when both ambulatory PA and varus thrust are treated simultaneously, rather than treating each separately.
AB - Introduction: This study aimed to examine the interaction effect between ambulatory physical activity (PA) and varus thrust on knee pain in individuals with knee osteoarthritis (OA). Method: Subjects (n = 207; mean age: 73.1 years, 71.5% women) in orthopedic clinics with diagnosed knee OA (Kellgren/Lawrence grade ≥ 1) were enrolled in this 12-month observational cohort study. Participants underwent gait observation for varus thrust assessment and pedometer-based ambulatory PA measurements at baseline and 12-month follow-up. Knee pain intensity was assessed using the Japanese Knee Osteoarthritis Measure pain subscale as a primary outcome measure. Multiple linear regression analyses were performed to evaluate ambulatory PA–thrust interaction on knee pain intensity. Results: Ninety-two subjects (mean age, 73.4 years; 68.5% women) completed the 12-month follow-up assessment. Baseline ambulatory PA–thrust interaction was significant (P = 0.017) in the cross-sectional analysis, adjusting for covariates, which yielded R2 = 0.310. Subgroup analysis showed that varus thrust was significantly associated with worse knee pain in subjects walking ≥ 5000 steps/day adjusting for covariates (beta: 7.94; 95% CI: 3.82, 12.1; P < 0.001) with a higher predictive ability (R2 = 0.664). In contrast, ambulatory PA–thrust interaction in the longitudinal analysis showed no significant association with knee pain changes. Conclusions: Ambulatory PA interacted with varus thrust in the association with knee pain, as coexisting high ambulatory PA and varus thrust had the strongest association with higher knee pain. Maximal pain relief effects might be achieved when both ambulatory PA and varus thrust are treated simultaneously, rather than treating each separately.
KW - Interaction
KW - Knee pain
KW - Physical activity
KW - Varus thrust
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U2 - 10.1007/s10067-019-04472-x
DO - 10.1007/s10067-019-04472-x
M3 - Article
C2 - 30847687
AN - SCOPUS:85062647535
VL - 38
SP - 1721
EP - 1729
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 6
ER -