Effects of intravascular latex injection on factors responsible for acute lung injury

A. Ishizaka, Naoki Hasegawa, K. Sayama, T. Urano, F. Sakamaki, H. Nakamura, S. Tasaka, M. Kanazawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To study the contribution of phagocytosis to the development of acute lung injury, latex particles (2 x 109/kg; mean diameter, 2.84 μm) were injected intravenously or intra-arterially into guinea pigs. 125I-labelled albumin was injected to estimate the degree of lung injury, and 51Cr-labelled red blood cells were injected to correct for blood contamination in the samples. A control group was given saline. Four hours after the injections, the animals were killed, bronchoalveolar lavage was done, and the lungs were examined histopathologically. Animals that had received intravenous and intra-arterial injections of latex particles had more lung water and more pulmonary albumin leakage than animals that had received saline. Histopathological examination revealed massive accumulation of latex in the reticuloendothelial system. These findings suggest that the phagocytic process in the reticuloendothelial system plays a role in the development of lung injury in guinea pigs.

Original languageEnglish
Pages (from-to)930-935
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume33
Issue number9
Publication statusPublished - 1995

Fingerprint

Acute Lung Injury
Latex
Mononuclear Phagocyte System
Lung Injury
Microspheres
Lung
Injections
Albumins
Guinea Pigs
Intra-Arterial Injections
Bronchoalveolar Lavage
Phagocytosis
Erythrocytes
Control Groups
Water

Keywords

  • Acute lung injury
  • Capillary permeability
  • Latex
  • Pulmonary edema
  • Reticuloendothelial system

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ishizaka, A., Hasegawa, N., Sayama, K., Urano, T., Sakamaki, F., Nakamura, H., ... Kanazawa, M. (1995). Effects of intravascular latex injection on factors responsible for acute lung injury. Japanese Journal of Thoracic Diseases, 33(9), 930-935.

Effects of intravascular latex injection on factors responsible for acute lung injury. / Ishizaka, A.; Hasegawa, Naoki; Sayama, K.; Urano, T.; Sakamaki, F.; Nakamura, H.; Tasaka, S.; Kanazawa, M.

In: Japanese Journal of Thoracic Diseases, Vol. 33, No. 9, 1995, p. 930-935.

Research output: Contribution to journalArticle

Ishizaka, A, Hasegawa, N, Sayama, K, Urano, T, Sakamaki, F, Nakamura, H, Tasaka, S & Kanazawa, M 1995, 'Effects of intravascular latex injection on factors responsible for acute lung injury', Japanese Journal of Thoracic Diseases, vol. 33, no. 9, pp. 930-935.
Ishizaka, A. ; Hasegawa, Naoki ; Sayama, K. ; Urano, T. ; Sakamaki, F. ; Nakamura, H. ; Tasaka, S. ; Kanazawa, M. / Effects of intravascular latex injection on factors responsible for acute lung injury. In: Japanese Journal of Thoracic Diseases. 1995 ; Vol. 33, No. 9. pp. 930-935.
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