Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

Masao Hattori; Kumi Miyachi; Sumitra Hada; Nobuko Kakiuchi; Tsuneo Namba; Fumiyuki Kiuchi; Yoshisuke Tsuda

doi:10.1248/cpb.35.3507

Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

Masao Hattori, Kumi Miyachi, Sumitra Hada, Nobuko Kakiuchi, Tsuneo Namba, Fumiyuki Kiuchi, Yoshisuke Tsuda

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.

Original language	English
Pages (from-to)	3507-3510
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	8
DOIs	https://doi.org/10.1248/cpb.35.3507
Publication status	Published - 1987
Externally published	Yes

Keywords

Streptococcus mutans
antibacterial action
dental caries
fatty acid
fatty alcohol
plaque control

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans",

abstract = "Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.",

keywords = "Streptococcus mutans, antibacterial action, dental caries, fatty acid, fatty alcohol, plaque control",

author = "Masao Hattori and Kumi Miyachi and Sumitra Hada and Nobuko Kakiuchi and Tsuneo Namba and Fumiyuki Kiuchi and Yoshisuke Tsuda",

year = "1987",

doi = "10.1248/cpb.35.3507",

language = "English",

volume = "35",

pages = "3507--3510",

journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

AU - Hattori, Masao

AU - Miyachi, Kumi

AU - Hada, Sumitra

AU - Kakiuchi, Nobuko

AU - Namba, Tsuneo

AU - Kiuchi, Fumiyuki

AU - Tsuda, Yoshisuke

PY - 1987

Y1 - 1987

N2 - Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.

AB - Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.

KW - Streptococcus mutans

KW - antibacterial action

KW - dental caries

KW - fatty acid

KW - fatty alcohol

KW - plaque control

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Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

Abstract

Keywords

ASJC Scopus subject areas

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