Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

Mamoru Sasaki, Shotaro Chubachi, Naofumi Kameyama, Minako Sato, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Takayoshi Nakano, Yukiko Kuroda, Tomoko Betsuyaku, Koichi Matsuo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.

Original languageEnglish
Article numbere0191611
JournalPLoS One
Volume13
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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bone metabolism
cigarettes
Emphysema
smoke
Metabolism
Smoke
Tobacco Products
long term effects
Bone
animal models
bones
Bone and Bones
Smoking
Chronic Obstructive Pulmonary Disease
Pulmonary diseases
respiratory tract diseases
Apatites
Confusion
Pulmonary Emphysema
Lumbar Vertebrae

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema. / Sasaki, Mamoru; Chubachi, Shotaro; Kameyama, Naofumi; Sato, Minako; Haraguchi, Mizuha; Miyazaki, Masaki; Takahashi, Saeko; Nakano, Takayoshi; Kuroda, Yukiko; Betsuyaku, Tomoko; Matsuo, Koichi.

In: PLoS One, Vol. 13, No. 1, e0191611, 01.01.2018.

Research output: Contribution to journalArticle

Sasaki, Mamoru ; Chubachi, Shotaro ; Kameyama, Naofumi ; Sato, Minako ; Haraguchi, Mizuha ; Miyazaki, Masaki ; Takahashi, Saeko ; Nakano, Takayoshi ; Kuroda, Yukiko ; Betsuyaku, Tomoko ; Matsuo, Koichi. / Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema. In: PLoS One. 2018 ; Vol. 13, No. 1.
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