Abstract
Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.
| Original language | English |
|---|---|
| Pages (from-to) | 1805-1810 |
| Number of pages | 6 |
| Journal | Clinical Neurophysiology |
| Volume | 126 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2015 Sep 1 |
| Externally published | Yes |
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Keywords
- Chronic inflammatory demyelinating polyneuropathy
- CIDP
- Demyelination
- Distal compound muscle action potential duration
- Electrodiagnosis
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP : A Japanese-European multicenter prospective study. / The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group.
In: Clinical Neurophysiology, Vol. 126, No. 9, 01.09.2015, p. 1805-1810.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP
T2 - A Japanese-European multicenter prospective study
AU - The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group
AU - Mitsuma, Satsuki
AU - Van den Bergh, Peter
AU - Rajabally, Yusuf A.
AU - Van Parijs, Vinciane
AU - Martin-Lamb, Darren
AU - Sonoo, Masahiro
AU - Inaba, Akira
AU - Shimizu, Toshio
AU - Isose, Sagiri
AU - Sato, Yasunori
AU - Komori, Tetsuo
AU - Misawa, Sonoko
AU - Kuwabara, Satoshi
AU - Kuwabara, S.
AU - Isose, S.
AU - Misawa, S.
AU - Sekiguchi, Y.
AU - Shibuya, K.
AU - Sonoo, M.
AU - Shimizu, T.
AU - Komori, T.
AU - Abe, T.
AU - Inaba, A.
AU - Yokota, T.
AU - Kanouchi, T.
AU - Kokubun, N.
AU - Nagashima, T.
AU - Tamura, A.
AU - Ohishi, C.
AU - Hirashima, F.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.
AB - Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.
KW - Chronic inflammatory demyelinating polyneuropathy
KW - CIDP
KW - Demyelination
KW - Distal compound muscle action potential duration
KW - Electrodiagnosis
UR - http://www.scopus.com/inward/record.url?scp=84938949452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938949452&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2014.11.027
DO - 10.1016/j.clinph.2014.11.027
M3 - Article
C2 - 25591830
AN - SCOPUS:84938949452
VL - 126
SP - 1805
EP - 1810
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 9
ER -