Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP: A Japanese-European multicenter prospective study

The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.

Original languageEnglish
Pages (from-to)1805-1810
Number of pages6
JournalClinical Neurophysiology
Volume126
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1
Externally publishedYes

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Action Potentials
Multicenter Studies
Prospective Studies
Muscles
Diabetic Neuropathies
Demyelinating Diseases
ROC Curve
Reference Values

Keywords

  • Chronic inflammatory demyelinating polyneuropathy
  • CIDP
  • Demyelination
  • Distal compound muscle action potential duration
  • Electrodiagnosis

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP : A Japanese-European multicenter prospective study. / The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group.

In: Clinical Neurophysiology, Vol. 126, No. 9, 01.09.2015, p. 1805-1810.

Research output: Contribution to journalArticle

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title = "Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP: A Japanese-European multicenter prospective study",
abstract = "Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100{\%} specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51{\%} to 66{\%}, and a specificity versus diabetic neuropathy from 96{\%} to 98{\%}. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.",
keywords = "Chronic inflammatory demyelinating polyneuropathy, CIDP, Demyelination, Distal compound muscle action potential duration, Electrodiagnosis",
author = "{The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group} and Satsuki Mitsuma and {Van den Bergh}, Peter and Rajabally, {Yusuf A.} and {Van Parijs}, Vinciane and Darren Martin-Lamb and Masahiro Sonoo and Akira Inaba and Toshio Shimizu and Sagiri Isose and Yasunori Sato and Tetsuo Komori and Sonoko Misawa and Satoshi Kuwabara and S. Kuwabara and S. Isose and S. Misawa and Y. Sekiguchi and K. Shibuya and M. Sonoo and T. Shimizu and T. Komori and T. Abe and A. Inaba and T. Yokota and T. Kanouchi and N. Kokubun and T. Nagashima and A. Tamura and C. Ohishi and F. Hirashima",
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T1 - Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP

T2 - A Japanese-European multicenter prospective study

AU - The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

AU - Mitsuma, Satsuki

AU - Van den Bergh, Peter

AU - Rajabally, Yusuf A.

AU - Van Parijs, Vinciane

AU - Martin-Lamb, Darren

AU - Sonoo, Masahiro

AU - Inaba, Akira

AU - Shimizu, Toshio

AU - Isose, Sagiri

AU - Sato, Yasunori

AU - Komori, Tetsuo

AU - Misawa, Sonoko

AU - Kuwabara, Satoshi

AU - Kuwabara, S.

AU - Isose, S.

AU - Misawa, S.

AU - Sekiguchi, Y.

AU - Shibuya, K.

AU - Sonoo, M.

AU - Shimizu, T.

AU - Komori, T.

AU - Abe, T.

AU - Inaba, A.

AU - Yokota, T.

AU - Kanouchi, T.

AU - Kokubun, N.

AU - Nagashima, T.

AU - Tamura, A.

AU - Ohishi, C.

AU - Hirashima, F.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.

AB - Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20. Hz. We aimed to provide widely-available reference data using several low cut filters. Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20. Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls. Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%. Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting. Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories.

KW - Chronic inflammatory demyelinating polyneuropathy

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KW - Demyelination

KW - Distal compound muscle action potential duration

KW - Electrodiagnosis

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