Effects of melophlins on colony formation of Chinese hamster V79 cells and IL-8 production in PMA-stimulated HL-60 cells

Taiko Oda, Ayako Fujita, Jinzhong Xu, Masataka Mochizuki, Kazuyo Ukai, Michio Namikoshi

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9 Citations (Scopus)

Abstract

We have recently isolated four new melophlins P (1), Q (2), R (3), and S (4) together with seven known melophlins A (5), D (6), E (7), G (8), H (9), I (10), and O (11) from two marine sponges of the genus Melophlus collected in Palau. In this study, the influence of these compounds on the colony formation of Chinese hamster V79 cells and the production of IL-8 in PMA-stimulated HL-60 cells were examined. These 11 compounds did not show any effect on IL-8 production. The EC50 values of compounds 2, 3, 4, 5, 7, 9, 10, and 11 against V79 cells were 44.0, 13.3, 16.7, 27.2, 19.8, 8.5, 23.1, and 9.6 μM, respectively. The linear-chain-type compounds (1, 6, and 8) were not active against V79 cells at 50 μM. Although the growth inhibitory activity of these melophlins was not remarkable, some structure-activity relationships of these compounds against V79 and murine leukemia L1210 cells were observed.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMarine Drugs
Volume5
Issue number1
DOIs
Publication statusPublished - 2007 Mar

Keywords

  • Cell proliferation
  • Marine sponge
  • Melophlin
  • Melophlus sp.
  • V79 cell

ASJC Scopus subject areas

  • Drug Discovery

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