Effects of neuropeptide Y on cochlear blood flow in guinea pigs

M. Itou, Kaoru Ogawa, Y. Inoue, M. Sato, J. Kanzaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalActa Oto-Laryngologica
Volume121
Issue number5
Publication statusPublished - 2001

Fingerprint

Neuropeptide Y
Cochlea
Guinea Pigs
Norepinephrine
Perfusion
Sudden Hearing Loss
Flowmeters
Sensorineural Hearing Loss
Lasers

Keywords

  • Cochlear blood flow
  • Noradrenaline
  • Perilymphatic perfusion
  • Stress

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Itou, M., Ogawa, K., Inoue, Y., Sato, M., & Kanzaki, J. (2001). Effects of neuropeptide Y on cochlear blood flow in guinea pigs. Acta Oto-Laryngologica, 121(5), 573-578.

Effects of neuropeptide Y on cochlear blood flow in guinea pigs. / Itou, M.; Ogawa, Kaoru; Inoue, Y.; Sato, M.; Kanzaki, J.

In: Acta Oto-Laryngologica, Vol. 121, No. 5, 2001, p. 573-578.

Research output: Contribution to journalArticle

Itou, M, Ogawa, K, Inoue, Y, Sato, M & Kanzaki, J 2001, 'Effects of neuropeptide Y on cochlear blood flow in guinea pigs', Acta Oto-Laryngologica, vol. 121, no. 5, pp. 573-578.
Itou, M. ; Ogawa, Kaoru ; Inoue, Y. ; Sato, M. ; Kanzaki, J. / Effects of neuropeptide Y on cochlear blood flow in guinea pigs. In: Acta Oto-Laryngologica. 2001 ; Vol. 121, No. 5. pp. 573-578.
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