Effects of neuropeptide Y on cochlear blood flow in guinea pigs

M. Itou, K. Ogawa, Y. Inoue, M. Sato, J. Kanzaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalActa Oto-Laryngologica
Volume121
Issue number5
DOIs
Publication statusPublished - 2001 Jan 1

Keywords

  • Cochlear blood flow
  • Noradrenaline
  • Perilymphatic perfusion
  • Stress

ASJC Scopus subject areas

  • Otorhinolaryngology

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