Abstract
The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).
| Original language | English |
|---|---|
| Pages (from-to) | 1494-1497 |
| Number of pages | 4 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 30 |
| Issue number | 9 |
| Publication status | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. / Tanaka, K.; Gotoh, F.; Muramatsu, F.; Fukuuchi, Y.; Amano, T.; Okayasu, H.; Suzuki, N.
In: Arzneimittel-Forschung/Drug Research, Vol. 30, No. 9, 1980, p. 1494-1497.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of nimodipine (Bay e 9736) on cerebral circulation in cats
AU - Tanaka, K.
AU - Gotoh, F.
AU - Muramatsu, F.
AU - Fukuuchi, Y.
AU - Amano, T.
AU - Okayasu, H.
AU - Suzuki, N.
PY - 1980
Y1 - 1980
N2 - The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).
AB - The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).
UR - http://www.scopus.com/inward/record.url?scp=0018855244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018855244&partnerID=8YFLogxK
M3 - Article
C2 - 7193015
AN - SCOPUS:0018855244
VL - 30
SP - 1494
EP - 1497
JO - Drug Research
JF - Drug Research
SN - 2194-9379
IS - 9
ER -