Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

K. Tanaka; F. Gotoh; F. Muramatsu; Y. Fukuuchi; T. Amano; H. Okayasu; N. Suzuki

Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, T. Amano, H. Okayasu, N. Suzuki

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

Original language	English
Pages (from-to)	1494-1497
Number of pages	4
Journal	Arzneimittel-Forschung/Drug Research
Volume	30
Issue number	9
Publication status	Published - 1980 Nov 10

ASJC Scopus subject areas

Drug Discovery

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title = "Effects of nimodipine (Bay e 9736) on cerebral circulation in cats",

abstract = "The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).",

author = "K. Tanaka and F. Gotoh and F. Muramatsu and Y. Fukuuchi and T. Amano and H. Okayasu and N. Suzuki",

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T1 - Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

AU - Tanaka, K.

AU - Gotoh, F.

AU - Muramatsu, F.

AU - Fukuuchi, Y.

AU - Amano, T.

AU - Okayasu, H.

AU - Suzuki, N.

PY - 1980/11/10

Y1 - 1980/11/10

N2 - The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

AB - The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

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