Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, T. Amano, H. Okayasu, N. Suzuki

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

Original languageEnglish
Pages (from-to)1494-1497
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume30
Issue number9
Publication statusPublished - 1980
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Nimodipine
Cats
Arteries
Felidae
Blood pressure
Dilatation
Arterial Pressure
Cameras

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Tanaka, K., Gotoh, F., Muramatsu, F., Fukuuchi, Y., Amano, T., Okayasu, H., & Suzuki, N. (1980). Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. Arzneimittel-Forschung/Drug Research, 30(9), 1494-1497.

Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. / Tanaka, K.; Gotoh, F.; Muramatsu, F.; Fukuuchi, Y.; Amano, T.; Okayasu, H.; Suzuki, N.

In: Arzneimittel-Forschung/Drug Research, Vol. 30, No. 9, 1980, p. 1494-1497.

Research output: Contribution to journalArticle

Tanaka, K, Gotoh, F, Muramatsu, F, Fukuuchi, Y, Amano, T, Okayasu, H & Suzuki, N 1980, 'Effects of nimodipine (Bay e 9736) on cerebral circulation in cats', Arzneimittel-Forschung/Drug Research, vol. 30, no. 9, pp. 1494-1497.
Tanaka K, Gotoh F, Muramatsu F, Fukuuchi Y, Amano T, Okayasu H et al. Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. Arzneimittel-Forschung/Drug Research. 1980;30(9):1494-1497.
Tanaka, K. ; Gotoh, F. ; Muramatsu, F. ; Fukuuchi, Y. ; Amano, T. ; Okayasu, H. ; Suzuki, N. / Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. In: Arzneimittel-Forschung/Drug Research. 1980 ; Vol. 30, No. 9. pp. 1494-1497.
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