Effects of nimodipine (Bay e 9736) on cerebral circulation in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, T. Amano, H. Okayasu, N. Suzuki

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Abstract

The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl 4-nitrophenyl-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 μ) than in the larger ones (≥ 100μ).

Original languageEnglish
Pages (from-to)1494-1497
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume30
Issue number9
Publication statusPublished - 1980 Nov 10

ASJC Scopus subject areas

  • Drug Discovery

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    Tanaka, K., Gotoh, F., Muramatsu, F., Fukuuchi, Y., Amano, T., Okayasu, H., & Suzuki, N. (1980). Effects of nimodipine (Bay e 9736) on cerebral circulation in cats. Arzneimittel-Forschung/Drug Research, 30(9), 1494-1497.