Effects of organic solvents on drug incorporation into polymeric carriers and morphological analyses of drug-incorporated polymeric micelles

Yoshiko Harada, Tatsuhiro Yamamoto, Masaru Sakai, Toshiharu Saiki, Kumi Kawano, Yoshie Maitani, Masayuki Yokoyama

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    We incorporated an anticancer agent, camptothecin (CPT), into polymeric micelle carriers by using two different solvents (TFE and chloroform) in the solvent-evaporation drug incorporation process. We observed significant differences in the drug-incorporation behaviors, in the morphologies of the incorporated drug and the polymeric micelles, and in the pharmacokinetic behaviors between the two solvents' cases. In particular, the CPT-incorporated polymeric micelles prepared with TFE as the incorporation solvent exhibited more stable circulation in blood than those prepared with chloroform. This contrast indicates a novel technological perspective regarding the drug incorporation into polymeric micelle carriers. Morphological analyses of the inner core have revealed the presence of the directed alignment of the CPT molecules and CPT crystals in the micelle inner core. This is the first report of the morphologies of the drug incorporated into the polymeric micelle inner cores. We believe these analyses are very important for further pharmaceutical developments of polymeric micelle drug-carrier systems.

    Original languageEnglish
    Pages (from-to)271-280
    Number of pages10
    JournalInternational Journal of Pharmaceutics
    Volume404
    Issue number1-2
    DOIs
    Publication statusPublished - 2011 Feb 14

    Keywords

    • Camptothecin
    • Incorporation
    • Inner core
    • Morphology
    • Polymeric micelle
    • Targeting

    ASJC Scopus subject areas

    • Pharmaceutical Science

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