Abstract
The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 ± 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 ± 14 to 101 ± 10 mm Hg), FPG (8.6 ± 1.4 to 7.0 ± 1.0 mmol/L), serum insulin (54 ± 11 to 30 ± 8 pmol/L, P < .01 for all), and HbA1c (6.7 ± 0.8 to 6.1% ± 0.6%, P = .013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 ± 3.2 to 27.0 ± 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 ± 24 to 138 ± 24 mg/dL) and SAT (155 ± 69 to 179 ± 81cm2, P < .05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 ± 1.7 to 14.4 ± 2.1 μg/mL, P = .005). VAT tended to increase (165 ± 38 to 180 ± 46 cm2) and VAT/SAT ratio tended to decrease (1.2 ± 0.3 to 1.1 ± 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level.
| Original language | English |
|---|---|
| Pages (from-to) | 314-317 |
| Number of pages | 4 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. / Hirose, Hiroshi; Kawai, Toshihide; Yamamoto, Yukihiro; Taniyama, Matsuo; Tomita, Motowo; Matsubara, Koichi; Okazaki, Yasunori; Ishii, Tatsuya; Oguma, Yuko; Takei, Izumi; Saruta, Takao.
In: Metabolism: Clinical and Experimental, Vol. 51, No. 3, 2002, p. 314-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
AU - Hirose, Hiroshi
AU - Kawai, Toshihide
AU - Yamamoto, Yukihiro
AU - Taniyama, Matsuo
AU - Tomita, Motowo
AU - Matsubara, Koichi
AU - Okazaki, Yasunori
AU - Ishii, Tatsuya
AU - Oguma, Yuko
AU - Takei, Izumi
AU - Saruta, Takao
PY - 2002
Y1 - 2002
N2 - The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 ± 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 ± 14 to 101 ± 10 mm Hg), FPG (8.6 ± 1.4 to 7.0 ± 1.0 mmol/L), serum insulin (54 ± 11 to 30 ± 8 pmol/L, P < .01 for all), and HbA1c (6.7 ± 0.8 to 6.1% ± 0.6%, P = .013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 ± 3.2 to 27.0 ± 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 ± 24 to 138 ± 24 mg/dL) and SAT (155 ± 69 to 179 ± 81cm2, P < .05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 ± 1.7 to 14.4 ± 2.1 μg/mL, P = .005). VAT tended to increase (165 ± 38 to 180 ± 46 cm2) and VAT/SAT ratio tended to decrease (1.2 ± 0.3 to 1.1 ± 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level.
AB - The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 ± 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 ± 14 to 101 ± 10 mm Hg), FPG (8.6 ± 1.4 to 7.0 ± 1.0 mmol/L), serum insulin (54 ± 11 to 30 ± 8 pmol/L, P < .01 for all), and HbA1c (6.7 ± 0.8 to 6.1% ± 0.6%, P = .013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 ± 3.2 to 27.0 ± 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 ± 24 to 138 ± 24 mg/dL) and SAT (155 ± 69 to 179 ± 81cm2, P < .05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 ± 1.7 to 14.4 ± 2.1 μg/mL, P = .005). VAT tended to increase (165 ± 38 to 180 ± 46 cm2) and VAT/SAT ratio tended to decrease (1.2 ± 0.3 to 1.1 ± 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level.
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U2 - 10.1053/meta.2002.30506
DO - 10.1053/meta.2002.30506
M3 - Article
VL - 51
SP - 314
EP - 317
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 3
ER -