Effects of pitavastatin in japanese patients with chronic heart failure - The pitavastatin heart failure study (PEARL study) -

Hiroyuki Takano, Hiroshi Mizuma, Yoichi Kuwabara, Yasunori Sato, Satoshi Shindo, Norihiko Kotooka, Daisuke Fujimatsu, Yoshio Kobayashi, Teruo Inoue, Koichi Node, Issei Komuro

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31 Citations (Scopus)

Abstract

Background: Recent clinical trials using rosuvastatin, a hydrophilic statin, did not show beneficial effects on cardiovascular events in patients with heart failure. We examined the cardioprotective effects of pitavastatin, a lipophilic statin, on Japanese patients with chronic heart failure (CHF). Methods and Results: A total of 574 Japanese patients with CHF were randomly assigned to the pitavastatin group (n=288) or the control group (n=286). There was no significant difference between the 2 groups for the primary outcome, which was a composite of cardiac death and hospitalization for worsening HF (adjusted hazard ratio (aHR): 0.922, 95% confidence interval (CI): 0.632-1.345, P=0.672). A strongly significant statistical interaction between the effect of pitavastatin and left ventricular ejection fraction (LVEF) was found (P=0.004). In patients with LVEF ≥30%, a significant reduction in the primary outcome (aHR: 0.525, 95% CI: 0.308-0.896, P=0.018) was observed in the pitavastatin group. Pitavastatin did not show any effects on the primary outcome (aHR: 1.582, 95% CI: 0.890-2.813, P=0.118) in the subgroup of patients with LVEF <30%. Conclusions: Pitavastatin did not reduce cardiac death or hospitalization for worsening HF in Japanese patients with CHF. (UMIN-ID: UMINC000000428).

Original languageEnglish
Pages (from-to)917-925
Number of pages9
JournalCirculation Journal
Volume77
Issue number4
DOIs
Publication statusPublished - 2013 Apr 3
Externally publishedYes

Keywords

  • Heart failure
  • Hypercholesterolemia
  • Pitavastatin
  • Randomized controlled trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Takano, H., Mizuma, H., Kuwabara, Y., Sato, Y., Shindo, S., Kotooka, N., Fujimatsu, D., Kobayashi, Y., Inoue, T., Node, K., & Komuro, I. (2013). Effects of pitavastatin in japanese patients with chronic heart failure - The pitavastatin heart failure study (PEARL study) -. Circulation Journal, 77(4), 917-925. https://doi.org/10.1253/circj.CJ-12-1062