Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017

Invasive Pneumococcal Diseases Surveillance Study Group

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To clarify year-to-year changes in capsular serotypes, resistance genotypes, and multilocus sequence types of Streptococcus pneumoniae, we compared isolates collected from patients with invasive pneumococcal disease before and after introductions of 7-and 13-valent pneumococcal conjugate vaccines (PCV7 and PVC13, respectively). From April 2010 through March 2017, we collected 2,856 isolates from children and adults throughout Japan. Proportions of PCV13 serotypes among children decreased from 89.0% in fiscal year 2010 to 12.1% in fiscal year 2016 and among adults from 74.1% to 36.2%. Although nonvaccine serotypes increased after introduction of PCV13, genotypic penicillin resistance decreased from 54.3% in 2010 to 11.2% in 2016 among children and from 32.4% to 15.5% among adults. However, genotypic penicillin resistance emerged in 9 nonvaccine serotypes, but not 15A and 35B. Multilocus sequence typing suggested that resistant strains among nonvaccine serotypes may have evolved from clonal complexes 156 and 81. A more broadly effective vaccine is needed.

Original languageEnglish
Pages (from-to)2010-2020
Number of pages11
JournalEmerging Infectious Diseases
Volume24
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

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Penicillin Resistance
Conjugate Vaccines
Pneumococcal Vaccines
Japan
Multilocus Sequence Typing
Streptococcus pneumoniae
Vaccines
Genotype
Serogroup

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017. / Invasive Pneumococcal Diseases Surveillance Study Group.

In: Emerging Infectious Diseases, Vol. 24, No. 11, 01.11.2018, p. 2010-2020.

Research output: Contribution to journalArticle

Invasive Pneumococcal Diseases Surveillance Study Group. / Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010–2017. In: Emerging Infectious Diseases. 2018 ; Vol. 24, No. 11. pp. 2010-2020.
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