Effects of polybrominated diphenol ethers from a marine sponge Phyllospongia dendyi on IL-8 production in a PMA- stimulated promyelocytic leukemia cell line

Taiko Oda, Hongwei Liu, Michio Namikoshi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalMarine Drugs
Volume3
Issue number4
DOIs
Publication statusPublished - 2005 Dec 1

Keywords

  • HL-60 cell
  • IL-8
  • Polybrominated diphenol ether
  • Relative plating efficiency
  • V79 cell

ASJC Scopus subject areas

  • Drug Discovery

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