Effects of prostaglandin E2 on gastric irritant-induced apoptosis

Tatsuya Hoshino; Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tomofusa Tsuchiya; Tohru Mizushima

doi:10.1023/A:1020164000898

Effects of prostaglandin E₂ on gastric irritant-induced apoptosis

Tatsuya Hoshino, Tatsunori Takano, Shinji Tsutsumi, Wataru Tomisato, Tomofusa Tsuchiya, Tohru Mizushima

School of Pharmacy

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

We previously reported that various gastric irritants induced both apoptosis and necrosis in cultured gastric mucosal cells. In a continuation of this work, the present study has examined the effects of prostaglandin E₂ (PGE₂), a cytoprotective factor for gastric mucosa in vivo, on gastric irritant-induced apoptosis and necrosis in vitro. PGE₂ inhibited ethanol-induced apoptosis and increased cell viability in a dose-dependent manner in primary cultures of guinea pig gastric mucosal cells. PGE₂ also inhibited hydrogen peroxide-induced apoptosis. In contrast, PGE₂ showed no cytoprotective effects against ethanol-induced necrosis. Based on these results, we consider that the cytoprotective effects of PGE₂ on gastric mucosa in vivo can be partially explained by its inhibitory effect on gastric irritant-induced apoptosis.

Original language	English
Pages (from-to)	2370-2379
Number of pages	10
Journal	Digestive Diseases and Sciences
Volume	47
Issue number	10
DOIs	https://doi.org/10.1023/A:1020164000898
Publication status	Published - 2002 Oct 1

Keywords

Apoptosis
Gastric irritants
Gastric mucosal cells
Necrosis
Prostaglandin E

ASJC Scopus subject areas

Physiology
Gastroenterology

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Hoshino, T., Takano, T., Tsutsumi, S., Tomisato, W., Tsuchiya, T., & Mizushima, T. (2002). Effects of prostaglandin E₂ on gastric irritant-induced apoptosis. Digestive Diseases and Sciences, 47(10), 2370-2379. https://doi.org/10.1023/A:1020164000898

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