Abstract
We previously reported that various gastric irritants induced both apoptosis and necrosis in cultured gastric mucosal cells. In a continuation of this work, the present study has examined the effects of prostaglandin E2 (PGE2), a cytoprotective factor for gastric mucosa in vivo, on gastric irritant-induced apoptosis and necrosis in vitro. PGE2 inhibited ethanol-induced apoptosis and increased cell viability in a dose-dependent manner in primary cultures of guinea pig gastric mucosal cells. PGE2 also inhibited hydrogen peroxide-induced apoptosis. In contrast, PGE2 showed no cytoprotective effects against ethanol-induced necrosis. Based on these results, we consider that the cytoprotective effects of PGE2 on gastric mucosa in vivo can be partially explained by its inhibitory effect on gastric irritant-induced apoptosis.
Original language | English |
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Pages (from-to) | 2370-2379 |
Number of pages | 10 |
Journal | Digestive Diseases and Sciences |
Volume | 47 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2002 Oct 1 |
Externally published | Yes |
Keywords
- Apoptosis
- Gastric irritants
- Gastric mucosal cells
- Necrosis
- Prostaglandin E
ASJC Scopus subject areas
- Physiology
- Gastroenterology