Effects of prostaglandin E2 on gastric irritant-induced apoptosis

Tatsuya Hoshino, Tatsunori Takano, Shinji Tsutsumi, Wataru Tomisato, Tomofusa Tsuchiya, Tohru Mizushima

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18 Citations (Scopus)

Abstract

We previously reported that various gastric irritants induced both apoptosis and necrosis in cultured gastric mucosal cells. In a continuation of this work, the present study has examined the effects of prostaglandin E2 (PGE2), a cytoprotective factor for gastric mucosa in vivo, on gastric irritant-induced apoptosis and necrosis in vitro. PGE2 inhibited ethanol-induced apoptosis and increased cell viability in a dose-dependent manner in primary cultures of guinea pig gastric mucosal cells. PGE2 also inhibited hydrogen peroxide-induced apoptosis. In contrast, PGE2 showed no cytoprotective effects against ethanol-induced necrosis. Based on these results, we consider that the cytoprotective effects of PGE2 on gastric mucosa in vivo can be partially explained by its inhibitory effect on gastric irritant-induced apoptosis.

Original languageEnglish
Pages (from-to)2370-2379
Number of pages10
JournalDigestive Diseases and Sciences
Volume47
Issue number10
DOIs
Publication statusPublished - 2002 Oct 1

Keywords

  • Apoptosis
  • Gastric irritants
  • Gastric mucosal cells
  • Necrosis
  • Prostaglandin E

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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    Hoshino, T., Takano, T., Tsutsumi, S., Tomisato, W., Tsuchiya, T., & Mizushima, T. (2002). Effects of prostaglandin E2 on gastric irritant-induced apoptosis. Digestive Diseases and Sciences, 47(10), 2370-2379. https://doi.org/10.1023/A:1020164000898