Effects of salt concentrations on the structural transitions of peptide-amphiphile solution

Takahiro Otsuka, Atsushi Hotta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A new peptide amphiphile (PA) called C16-W3K has hierarchical structures, presenting unique solution states, micelle structures, and secondary structures. In this work, the effects of salt (sodium dihydrogenorthophosphate) concentration on the hierarchical structural transitions of the C16-W3K solution due to its active hydrogen bonding in the peptide were discussed. In order to analyze the effects of salt on the structural transitions, the mechanical and structural analyses were conducted by viscosity measurements, transmission electron microscopy (TEM), and circular dichroic (CD) spectroscopy. It was found that the C16-W3K solutions with different salt concentrations presented different multi-scale structural transitions from spherical micelles with α-helix molecular conformations in the sol state to wormlike micelles with β-sheet conformations in the gel state. Additionally, we found that the speed of transition increased as the salt concentration increased and the conformational ratio of β-sheet to α-helix in the solutions increased with the increase in the salt concentration.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium Proceedings
PublisherMaterials Research Society
Volume1622
DOIs
Publication statusPublished - 2014
Event2013 MRS Fall Meeting - Boston, MA, United States
Duration: 2013 Dec 12013 Dec 6

Other

Other2013 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period13/12/113/12/6

Fingerprint

Amphiphiles
Peptides
peptides
Salts
salts
Micelles
micelles
helices
Conformations
Viscosity measurement
Polymethyl Methacrylate
Sols
Hydrogen bonds
Gels
Sodium
sodium
Spectroscopy
gels
viscosity
Transmission electron microscopy

Keywords

  • colloid
  • self-assembly
  • sol-gel

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Otsuka, T., & Hotta, A. (2014). Effects of salt concentrations on the structural transitions of peptide-amphiphile solution. In Materials Research Society Symposium Proceedings (Vol. 1622). Materials Research Society. https://doi.org/10.1557/opl.2014.40

Effects of salt concentrations on the structural transitions of peptide-amphiphile solution. / Otsuka, Takahiro; Hotta, Atsushi.

Materials Research Society Symposium Proceedings. Vol. 1622 Materials Research Society, 2014.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Otsuka, T & Hotta, A 2014, Effects of salt concentrations on the structural transitions of peptide-amphiphile solution. in Materials Research Society Symposium Proceedings. vol. 1622, Materials Research Society, 2013 MRS Fall Meeting, Boston, MA, United States, 13/12/1. https://doi.org/10.1557/opl.2014.40
Otsuka T, Hotta A. Effects of salt concentrations on the structural transitions of peptide-amphiphile solution. In Materials Research Society Symposium Proceedings. Vol. 1622. Materials Research Society. 2014 https://doi.org/10.1557/opl.2014.40
Otsuka, Takahiro ; Hotta, Atsushi. / Effects of salt concentrations on the structural transitions of peptide-amphiphile solution. Materials Research Society Symposium Proceedings. Vol. 1622 Materials Research Society, 2014.
@inproceedings{0e0f0c5ce645474787551567ca66608c,
title = "Effects of salt concentrations on the structural transitions of peptide-amphiphile solution",
abstract = "A new peptide amphiphile (PA) called C16-W3K has hierarchical structures, presenting unique solution states, micelle structures, and secondary structures. In this work, the effects of salt (sodium dihydrogenorthophosphate) concentration on the hierarchical structural transitions of the C16-W3K solution due to its active hydrogen bonding in the peptide were discussed. In order to analyze the effects of salt on the structural transitions, the mechanical and structural analyses were conducted by viscosity measurements, transmission electron microscopy (TEM), and circular dichroic (CD) spectroscopy. It was found that the C16-W3K solutions with different salt concentrations presented different multi-scale structural transitions from spherical micelles with α-helix molecular conformations in the sol state to wormlike micelles with β-sheet conformations in the gel state. Additionally, we found that the speed of transition increased as the salt concentration increased and the conformational ratio of β-sheet to α-helix in the solutions increased with the increase in the salt concentration.",
keywords = "colloid, self-assembly, sol-gel",
author = "Takahiro Otsuka and Atsushi Hotta",
year = "2014",
doi = "10.1557/opl.2014.40",
language = "English",
volume = "1622",
booktitle = "Materials Research Society Symposium Proceedings",
publisher = "Materials Research Society",

}

TY - GEN

T1 - Effects of salt concentrations on the structural transitions of peptide-amphiphile solution

AU - Otsuka, Takahiro

AU - Hotta, Atsushi

PY - 2014

Y1 - 2014

N2 - A new peptide amphiphile (PA) called C16-W3K has hierarchical structures, presenting unique solution states, micelle structures, and secondary structures. In this work, the effects of salt (sodium dihydrogenorthophosphate) concentration on the hierarchical structural transitions of the C16-W3K solution due to its active hydrogen bonding in the peptide were discussed. In order to analyze the effects of salt on the structural transitions, the mechanical and structural analyses were conducted by viscosity measurements, transmission electron microscopy (TEM), and circular dichroic (CD) spectroscopy. It was found that the C16-W3K solutions with different salt concentrations presented different multi-scale structural transitions from spherical micelles with α-helix molecular conformations in the sol state to wormlike micelles with β-sheet conformations in the gel state. Additionally, we found that the speed of transition increased as the salt concentration increased and the conformational ratio of β-sheet to α-helix in the solutions increased with the increase in the salt concentration.

AB - A new peptide amphiphile (PA) called C16-W3K has hierarchical structures, presenting unique solution states, micelle structures, and secondary structures. In this work, the effects of salt (sodium dihydrogenorthophosphate) concentration on the hierarchical structural transitions of the C16-W3K solution due to its active hydrogen bonding in the peptide were discussed. In order to analyze the effects of salt on the structural transitions, the mechanical and structural analyses were conducted by viscosity measurements, transmission electron microscopy (TEM), and circular dichroic (CD) spectroscopy. It was found that the C16-W3K solutions with different salt concentrations presented different multi-scale structural transitions from spherical micelles with α-helix molecular conformations in the sol state to wormlike micelles with β-sheet conformations in the gel state. Additionally, we found that the speed of transition increased as the salt concentration increased and the conformational ratio of β-sheet to α-helix in the solutions increased with the increase in the salt concentration.

KW - colloid

KW - self-assembly

KW - sol-gel

UR - http://www.scopus.com/inward/record.url?scp=84897984371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897984371&partnerID=8YFLogxK

U2 - 10.1557/opl.2014.40

DO - 10.1557/opl.2014.40

M3 - Conference contribution

AN - SCOPUS:84897984371

VL - 1622

BT - Materials Research Society Symposium Proceedings

PB - Materials Research Society

ER -