Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack

Koichi Miyaki, Yuji Nishiwaki, Kazuhiko Maekawa, Yasutaka Ogawa, Nozomu Asukai, Kimio Yoshimura, Norihito Etoh, Yukio Matsumoto, Yuriko Kikuchi, Nami Kumagai, Kazuyuki Omae

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

This study was designed to assess the after effects of sarin exposure on the nervous system in victims of the Tokyo Subway Sarin Attack, which occurred on 20 March, 1995. We performed a similar study 3 yr after the disaster. This time, we newly enrolled 36 staff of the Teito Rapid Transit Authority (Tokyo Eidan subway) to assess the 7 yr after effects on the nervous system, and merged previous data including unpublished data to enhance statistical power. New subjects consisted of 23 male exposed subjects and 13 referent subjects matched for age and working types. Neurobehavioral tests for psychomotor function and memory, stabilometry, and Benton visual retention test were performed. As reported previously, the exposed group performed significantly less well in the psychomotor function test (tapping) than the referent group (117.8 ± 1.2 vs. 105.6 ± 1.2 msec). Using merged data, this phenomenon was also observed in a dose-dependent manner and the exposed group performed significantly less well in the backward digit span test (4.47 ± 1.17 vs. 5.11 ± 1.65 digits). These results indicate that chronic decline of psychomotor function and memory function still exist 7 yr after the sarin exposure.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalJournal of Occupational Health
Volume47
Issue number4
DOIs
Publication statusPublished - 2005 Jul
Externally publishedYes

Fingerprint

Sarin
Railroads
Subways
Tokyo
Neurology
Nervous System
Data storage equipment
Rapid transit
Disasters

Keywords

  • Cross-sectional study
  • Neurotoxicity
  • Sarin
  • Terrorism
  • Tokyo Subway Sarin Attack

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack. / Miyaki, Koichi; Nishiwaki, Yuji; Maekawa, Kazuhiko; Ogawa, Yasutaka; Asukai, Nozomu; Yoshimura, Kimio; Etoh, Norihito; Matsumoto, Yukio; Kikuchi, Yuriko; Kumagai, Nami; Omae, Kazuyuki.

In: Journal of Occupational Health, Vol. 47, No. 4, 07.2005, p. 299-304.

Research output: Contribution to journalArticle

Miyaki, K, Nishiwaki, Y, Maekawa, K, Ogawa, Y, Asukai, N, Yoshimura, K, Etoh, N, Matsumoto, Y, Kikuchi, Y, Kumagai, N & Omae, K 2005, 'Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack', Journal of Occupational Health, vol. 47, no. 4, pp. 299-304. https://doi.org/10.1539/joh.47.299
Miyaki, Koichi ; Nishiwaki, Yuji ; Maekawa, Kazuhiko ; Ogawa, Yasutaka ; Asukai, Nozomu ; Yoshimura, Kimio ; Etoh, Norihito ; Matsumoto, Yukio ; Kikuchi, Yuriko ; Kumagai, Nami ; Omae, Kazuyuki. / Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack. In: Journal of Occupational Health. 2005 ; Vol. 47, No. 4. pp. 299-304.
@article{ff03e095b5cc4e79a3d96f09c2e839b7,
title = "Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack",
abstract = "This study was designed to assess the after effects of sarin exposure on the nervous system in victims of the Tokyo Subway Sarin Attack, which occurred on 20 March, 1995. We performed a similar study 3 yr after the disaster. This time, we newly enrolled 36 staff of the Teito Rapid Transit Authority (Tokyo Eidan subway) to assess the 7 yr after effects on the nervous system, and merged previous data including unpublished data to enhance statistical power. New subjects consisted of 23 male exposed subjects and 13 referent subjects matched for age and working types. Neurobehavioral tests for psychomotor function and memory, stabilometry, and Benton visual retention test were performed. As reported previously, the exposed group performed significantly less well in the psychomotor function test (tapping) than the referent group (117.8 ± 1.2 vs. 105.6 ± 1.2 msec). Using merged data, this phenomenon was also observed in a dose-dependent manner and the exposed group performed significantly less well in the backward digit span test (4.47 ± 1.17 vs. 5.11 ± 1.65 digits). These results indicate that chronic decline of psychomotor function and memory function still exist 7 yr after the sarin exposure.",
keywords = "Cross-sectional study, Neurotoxicity, Sarin, Terrorism, Tokyo Subway Sarin Attack",
author = "Koichi Miyaki and Yuji Nishiwaki and Kazuhiko Maekawa and Yasutaka Ogawa and Nozomu Asukai and Kimio Yoshimura and Norihito Etoh and Yukio Matsumoto and Yuriko Kikuchi and Nami Kumagai and Kazuyuki Omae",
year = "2005",
month = "7",
doi = "10.1539/joh.47.299",
language = "English",
volume = "47",
pages = "299--304",
journal = "Journal of Occupational Health",
issn = "1341-9145",
publisher = "Japan Society for Occupational Health",
number = "4",

}

TY - JOUR

T1 - Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack

AU - Miyaki, Koichi

AU - Nishiwaki, Yuji

AU - Maekawa, Kazuhiko

AU - Ogawa, Yasutaka

AU - Asukai, Nozomu

AU - Yoshimura, Kimio

AU - Etoh, Norihito

AU - Matsumoto, Yukio

AU - Kikuchi, Yuriko

AU - Kumagai, Nami

AU - Omae, Kazuyuki

PY - 2005/7

Y1 - 2005/7

N2 - This study was designed to assess the after effects of sarin exposure on the nervous system in victims of the Tokyo Subway Sarin Attack, which occurred on 20 March, 1995. We performed a similar study 3 yr after the disaster. This time, we newly enrolled 36 staff of the Teito Rapid Transit Authority (Tokyo Eidan subway) to assess the 7 yr after effects on the nervous system, and merged previous data including unpublished data to enhance statistical power. New subjects consisted of 23 male exposed subjects and 13 referent subjects matched for age and working types. Neurobehavioral tests for psychomotor function and memory, stabilometry, and Benton visual retention test were performed. As reported previously, the exposed group performed significantly less well in the psychomotor function test (tapping) than the referent group (117.8 ± 1.2 vs. 105.6 ± 1.2 msec). Using merged data, this phenomenon was also observed in a dose-dependent manner and the exposed group performed significantly less well in the backward digit span test (4.47 ± 1.17 vs. 5.11 ± 1.65 digits). These results indicate that chronic decline of psychomotor function and memory function still exist 7 yr after the sarin exposure.

AB - This study was designed to assess the after effects of sarin exposure on the nervous system in victims of the Tokyo Subway Sarin Attack, which occurred on 20 March, 1995. We performed a similar study 3 yr after the disaster. This time, we newly enrolled 36 staff of the Teito Rapid Transit Authority (Tokyo Eidan subway) to assess the 7 yr after effects on the nervous system, and merged previous data including unpublished data to enhance statistical power. New subjects consisted of 23 male exposed subjects and 13 referent subjects matched for age and working types. Neurobehavioral tests for psychomotor function and memory, stabilometry, and Benton visual retention test were performed. As reported previously, the exposed group performed significantly less well in the psychomotor function test (tapping) than the referent group (117.8 ± 1.2 vs. 105.6 ± 1.2 msec). Using merged data, this phenomenon was also observed in a dose-dependent manner and the exposed group performed significantly less well in the backward digit span test (4.47 ± 1.17 vs. 5.11 ± 1.65 digits). These results indicate that chronic decline of psychomotor function and memory function still exist 7 yr after the sarin exposure.

KW - Cross-sectional study

KW - Neurotoxicity

KW - Sarin

KW - Terrorism

KW - Tokyo Subway Sarin Attack

UR - http://www.scopus.com/inward/record.url?scp=25444489291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444489291&partnerID=8YFLogxK

U2 - 10.1539/joh.47.299

DO - 10.1539/joh.47.299

M3 - Article

C2 - 16096354

AN - SCOPUS:25444489291

VL - 47

SP - 299

EP - 304

JO - Journal of Occupational Health

JF - Journal of Occupational Health

SN - 1341-9145

IS - 4

ER -